IL-38 alleviates concanavalin A-induced liver injury in mice
Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induc...
Gespeichert in:
| Veröffentlicht in: | International immunopharmacology 2016-11, Vol.40, p.452-457 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 457 |
|---|---|
| container_issue | |
| container_start_page | 452 |
| container_title | International immunopharmacology |
| container_volume | 40 |
| creator | Yuan, Xianli Li, Yan Pan, Xiuhe Peng, Xiao Song, Gaihuan Jiang, Wenwen Gao, Qiaoyan Li, Mingcai |
| description | Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury. Transfer of plasmid DNA encoding IL-38 significantly reduced hepatic toxicity and serum levels of aspartate aminotransferase and alanine aminotransferase compared with administration of a control plasmid. Moreover, IL-38 expression dramatically reduced serum levels of several pro-inflammatory cytokines, such as tumor necrosis factor-α, interferon-γ, IL-6, IL-17, and IL-22, but not levels of the anti-inflammatory cytokine IL-10. These results suggest that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production.
•IL-38 inhibits Con A-induced liver injury in mice.•IL-38 reduces hepatic toxicity and serum levels of AST and ALT.•IL-38 decreases levels of TNF-α, IFN-γ, IL-6, IL-17, and IL-22 in Con A-treated mice.•IL-38 may offer a novel therapeutic approach to treat inflammatory liver diseases. |
| doi_str_mv | 10.1016/j.intimp.2016.09.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1932363934</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1567576916303976</els_id><sourcerecordid>1932363934</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-d145525808e89aa12d85b2141c73646bd01694a558207c6e1da82e3811c98b8f3</originalsourceid><addsrcrecordid>eNp9kFlLxDAUhYMojo7-A5GCz61Zmg1EGAaXgQFf9DmkSQZS2nRMF5h_b4aOPvp0F845l_sBcIdggSBij3Xhw-DbfYHTVEBZQEzOwBUSXOSIQ3qeesp4TjmTC3Dd9zWEaV-iS7DAnGNCmbwCT5ttTkSmm8ZNXg-uz0wXjA560o0P2Sr3wY7G2azxk4uZD_UYD6lkrTfuBlzsdNO721Ndgq_Xl8_1e779eNusV9vcEAmH3KKSUkwFFE5IrRG2glYYlchwwkpW2fSALDWlAkNumENWC-yIQMhIUYkdWYKHOXcfu-_R9YOquzGGdFIhSTBhRJIyqcpZZWLX99Ht1D76VseDQlAdkalazcjUEZmCUiVkyXZ_Ch-r1tk_0y-jJHieBS69OHkXVW-8CwmKj84Mynb-_ws_a3R7_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932363934</pqid></control><display><type>article</type><title>IL-38 alleviates concanavalin A-induced liver injury in mice</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Yuan, Xianli ; Li, Yan ; Pan, Xiuhe ; Peng, Xiao ; Song, Gaihuan ; Jiang, Wenwen ; Gao, Qiaoyan ; Li, Mingcai</creator><creatorcontrib>Yuan, Xianli ; Li, Yan ; Pan, Xiuhe ; Peng, Xiao ; Song, Gaihuan ; Jiang, Wenwen ; Gao, Qiaoyan ; Li, Mingcai</creatorcontrib><description>Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury. Transfer of plasmid DNA encoding IL-38 significantly reduced hepatic toxicity and serum levels of aspartate aminotransferase and alanine aminotransferase compared with administration of a control plasmid. Moreover, IL-38 expression dramatically reduced serum levels of several pro-inflammatory cytokines, such as tumor necrosis factor-α, interferon-γ, IL-6, IL-17, and IL-22, but not levels of the anti-inflammatory cytokine IL-10. These results suggest that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production.
•IL-38 inhibits Con A-induced liver injury in mice.•IL-38 reduces hepatic toxicity and serum levels of AST and ALT.•IL-38 decreases levels of TNF-α, IFN-γ, IL-6, IL-17, and IL-22 in Con A-treated mice.•IL-38 may offer a novel therapeutic approach to treat inflammatory liver diseases.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2016.09.023</identifier><identifier>PMID: 27723569</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Intravenous ; Alanine ; Alanine transaminase ; Alanine Transaminase - blood ; Animals ; Anti-inflammatory agents ; Aspartate aminotransferase ; Aspartate Aminotransferases - blood ; Biocompatibility ; Cell Survival ; Chemical and Drug Induced Liver Injury - immunology ; Concanavalin A ; Concanavalin A - immunology ; Cytokines ; Cytokines - blood ; Deoxyribonucleic acid ; DNA ; Drugs ; Experiments ; Gene transfer ; Gene Transfer Techniques ; Humans ; Hydrodynamic-based gene delivery ; IL-38 ; Inflammation ; Inflammation Mediators - blood ; Inflammatory cytokines ; Injury prevention ; Interferon ; Interleukin 1 ; Interleukin 10 ; Interleukin 17 ; Interleukin 22 ; Interleukin 6 ; Interleukins - genetics ; Interleukins - metabolism ; Liver ; Liver diseases ; Liver injury ; Male ; Mice ; Mice, Inbred BALB C ; Plasmids ; Rodents ; Serum levels ; Toxicity ; Transgenes - genetics ; Tumor necrosis factor-α ; γ-Interferon</subject><ispartof>International immunopharmacology, 2016-11, Vol.40, p.452-457</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Nov 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d145525808e89aa12d85b2141c73646bd01694a558207c6e1da82e3811c98b8f3</citedby><cites>FETCH-LOGICAL-c390t-d145525808e89aa12d85b2141c73646bd01694a558207c6e1da82e3811c98b8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2016.09.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27723569$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Xianli</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Pan, Xiuhe</creatorcontrib><creatorcontrib>Peng, Xiao</creatorcontrib><creatorcontrib>Song, Gaihuan</creatorcontrib><creatorcontrib>Jiang, Wenwen</creatorcontrib><creatorcontrib>Gao, Qiaoyan</creatorcontrib><creatorcontrib>Li, Mingcai</creatorcontrib><title>IL-38 alleviates concanavalin A-induced liver injury in mice</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury. Transfer of plasmid DNA encoding IL-38 significantly reduced hepatic toxicity and serum levels of aspartate aminotransferase and alanine aminotransferase compared with administration of a control plasmid. Moreover, IL-38 expression dramatically reduced serum levels of several pro-inflammatory cytokines, such as tumor necrosis factor-α, interferon-γ, IL-6, IL-17, and IL-22, but not levels of the anti-inflammatory cytokine IL-10. These results suggest that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production.
•IL-38 inhibits Con A-induced liver injury in mice.•IL-38 reduces hepatic toxicity and serum levels of AST and ALT.•IL-38 decreases levels of TNF-α, IFN-γ, IL-6, IL-17, and IL-22 in Con A-treated mice.•IL-38 may offer a novel therapeutic approach to treat inflammatory liver diseases.</description><subject>Administration, Intravenous</subject><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Anti-inflammatory agents</subject><subject>Aspartate aminotransferase</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biocompatibility</subject><subject>Cell Survival</subject><subject>Chemical and Drug Induced Liver Injury - immunology</subject><subject>Concanavalin A</subject><subject>Concanavalin A - immunology</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drugs</subject><subject>Experiments</subject><subject>Gene transfer</subject><subject>Gene Transfer Techniques</subject><subject>Humans</subject><subject>Hydrodynamic-based gene delivery</subject><subject>IL-38</subject><subject>Inflammation</subject><subject>Inflammation Mediators - blood</subject><subject>Inflammatory cytokines</subject><subject>Injury prevention</subject><subject>Interferon</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 17</subject><subject>Interleukin 22</subject><subject>Interleukin 6</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Liver injury</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Plasmids</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Toxicity</subject><subject>Transgenes - genetics</subject><subject>Tumor necrosis factor-α</subject><subject>γ-Interferon</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFlLxDAUhYMojo7-A5GCz61Zmg1EGAaXgQFf9DmkSQZS2nRMF5h_b4aOPvp0F845l_sBcIdggSBij3Xhw-DbfYHTVEBZQEzOwBUSXOSIQ3qeesp4TjmTC3Dd9zWEaV-iS7DAnGNCmbwCT5ttTkSmm8ZNXg-uz0wXjA560o0P2Sr3wY7G2azxk4uZD_UYD6lkrTfuBlzsdNO721Ndgq_Xl8_1e779eNusV9vcEAmH3KKSUkwFFE5IrRG2glYYlchwwkpW2fSALDWlAkNumENWC-yIQMhIUYkdWYKHOXcfu-_R9YOquzGGdFIhSTBhRJIyqcpZZWLX99Ht1D76VseDQlAdkalazcjUEZmCUiVkyXZ_Ch-r1tk_0y-jJHieBS69OHkXVW-8CwmKj84Mynb-_ws_a3R7_w</recordid><startdate>201611</startdate><enddate>201611</enddate><creator>Yuan, Xianli</creator><creator>Li, Yan</creator><creator>Pan, Xiuhe</creator><creator>Peng, Xiao</creator><creator>Song, Gaihuan</creator><creator>Jiang, Wenwen</creator><creator>Gao, Qiaoyan</creator><creator>Li, Mingcai</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>201611</creationdate><title>IL-38 alleviates concanavalin A-induced liver injury in mice</title><author>Yuan, Xianli ; Li, Yan ; Pan, Xiuhe ; Peng, Xiao ; Song, Gaihuan ; Jiang, Wenwen ; Gao, Qiaoyan ; Li, Mingcai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-d145525808e89aa12d85b2141c73646bd01694a558207c6e1da82e3811c98b8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Intravenous</topic><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alanine Transaminase - blood</topic><topic>Animals</topic><topic>Anti-inflammatory agents</topic><topic>Aspartate aminotransferase</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Biocompatibility</topic><topic>Cell Survival</topic><topic>Chemical and Drug Induced Liver Injury - immunology</topic><topic>Concanavalin A</topic><topic>Concanavalin A - immunology</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drugs</topic><topic>Experiments</topic><topic>Gene transfer</topic><topic>Gene Transfer Techniques</topic><topic>Humans</topic><topic>Hydrodynamic-based gene delivery</topic><topic>IL-38</topic><topic>Inflammation</topic><topic>Inflammation Mediators - blood</topic><topic>Inflammatory cytokines</topic><topic>Injury prevention</topic><topic>Interferon</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin 17</topic><topic>Interleukin 22</topic><topic>Interleukin 6</topic><topic>Interleukins - genetics</topic><topic>Interleukins - metabolism</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Liver injury</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Plasmids</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Toxicity</topic><topic>Transgenes - genetics</topic><topic>Tumor necrosis factor-α</topic><topic>γ-Interferon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Xianli</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Pan, Xiuhe</creatorcontrib><creatorcontrib>Peng, Xiao</creatorcontrib><creatorcontrib>Song, Gaihuan</creatorcontrib><creatorcontrib>Jiang, Wenwen</creatorcontrib><creatorcontrib>Gao, Qiaoyan</creatorcontrib><creatorcontrib>Li, Mingcai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Xianli</au><au>Li, Yan</au><au>Pan, Xiuhe</au><au>Peng, Xiao</au><au>Song, Gaihuan</au><au>Jiang, Wenwen</au><au>Gao, Qiaoyan</au><au>Li, Mingcai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-38 alleviates concanavalin A-induced liver injury in mice</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2016-11</date><risdate>2016</risdate><volume>40</volume><spage>452</spage><epage>457</epage><pages>452-457</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury. Transfer of plasmid DNA encoding IL-38 significantly reduced hepatic toxicity and serum levels of aspartate aminotransferase and alanine aminotransferase compared with administration of a control plasmid. Moreover, IL-38 expression dramatically reduced serum levels of several pro-inflammatory cytokines, such as tumor necrosis factor-α, interferon-γ, IL-6, IL-17, and IL-22, but not levels of the anti-inflammatory cytokine IL-10. These results suggest that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production.
•IL-38 inhibits Con A-induced liver injury in mice.•IL-38 reduces hepatic toxicity and serum levels of AST and ALT.•IL-38 decreases levels of TNF-α, IFN-γ, IL-6, IL-17, and IL-22 in Con A-treated mice.•IL-38 may offer a novel therapeutic approach to treat inflammatory liver diseases.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27723569</pmid><doi>10.1016/j.intimp.2016.09.023</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-5769 |
| ispartof | International immunopharmacology, 2016-11, Vol.40, p.452-457 |
| issn | 1567-5769 1878-1705 |
| language | eng |
| recordid | cdi_proquest_journals_1932363934 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Administration, Intravenous Alanine Alanine transaminase Alanine Transaminase - blood Animals Anti-inflammatory agents Aspartate aminotransferase Aspartate Aminotransferases - blood Biocompatibility Cell Survival Chemical and Drug Induced Liver Injury - immunology Concanavalin A Concanavalin A - immunology Cytokines Cytokines - blood Deoxyribonucleic acid DNA Drugs Experiments Gene transfer Gene Transfer Techniques Humans Hydrodynamic-based gene delivery IL-38 Inflammation Inflammation Mediators - blood Inflammatory cytokines Injury prevention Interferon Interleukin 1 Interleukin 10 Interleukin 17 Interleukin 22 Interleukin 6 Interleukins - genetics Interleukins - metabolism Liver Liver diseases Liver injury Male Mice Mice, Inbred BALB C Plasmids Rodents Serum levels Toxicity Transgenes - genetics Tumor necrosis factor-α γ-Interferon |
| title | IL-38 alleviates concanavalin A-induced liver injury in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T06%3A47%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IL-38%20alleviates%20concanavalin%20A-induced%20liver%20injury%20in%20mice&rft.jtitle=International%20immunopharmacology&rft.au=Yuan,%20Xianli&rft.date=2016-11&rft.volume=40&rft.spage=452&rft.epage=457&rft.pages=452-457&rft.issn=1567-5769&rft.eissn=1878-1705&rft_id=info:doi/10.1016/j.intimp.2016.09.023&rft_dat=%3Cproquest_cross%3E1932363934%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932363934&rft_id=info:pmid/27723569&rft_els_id=S1567576916303976&rfr_iscdi=true |