Selective inhibition of PKCβ2 preserves cardiac function after myocardial infarction and is associated with improved angiogenesis of ischemic myocardium in diabetic rats

Activation of PKCβ2 induced by hyperglycemia contributes to impaired angiogenesis in endothelial cells. The purpose of the present study was to investigate whether PKCβ2 inhibition can attenuate the hyperglycemia-induced impaired angiogenesis of myocardium to improve cardiac function following myoca...

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Veröffentlicht in:	International journal of molecular medicine 2013-11, Vol.32 (5), p.1037-1046
Hauptverfasser:	WANG, FABIN, HUANG, DONG, ZHU, WEI, LI, SHUAI, YAN, MEILING, WEI, MENG, LI, JINGBO
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Blotting, Western cardiac function Cell adhesion & migration Cell growth Cell Movement - drug effects Coronary vessels Diabetes Echocardiography Enzyme Inhibitors - therapeutic use Enzyme-Linked Immunosorbent Assay Heart - drug effects Heart attacks Heart failure Hemodynamics - drug effects Human Umbilical Vein Endothelial Cells Humans Immunohistochemistry Kinases Laboratory animals Male myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - metabolism Neovascularization, Physiologic - drug effects Ostomy Phosphorylation PKCβ2 Protein Kinase C beta - antagonists & inhibitors Rats Rats, Sprague-Dawley Vascular endothelial growth factor
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