Piceatannol inhibits mast cell-mediated allergic inflammation
Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by ex...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular medicine 2013-04, Vol.31 (4), p.951-958 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 958 |
|---|---|
| container_issue | 4 |
| container_start_page | 951 |
| container_title | International journal of molecular medicine |
| container_volume | 31 |
| creator | KO, YU-JIN KIM, HUI-HUN KIM, EUN-JUNG KATAKURA, YOSHINORI LEE, WON-SUP KIM, GON-SUP RYU, CHUNG-HO |
| description | Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro-inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases. |
| doi_str_mv | 10.3892/ijmm.2013.1283 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1932354209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1932354209</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-8920181804e96368a8b7cacd5f171f68a8a609ef63fee9d5a9997935014ec6763</originalsourceid><addsrcrecordid>eNo9kLtPwzAQhy0EoqWwMqJILCwOPtvxY2BAFS-pEgwgsVmu44CrPEqcDPz3OGrp5LP03e_uPoQugeRMaXobNk2TUwIsB6rYEZqD1IAp55_HqQYiMZOFmKGzGDeE0IJrdYpmlHEqlIQ5unsLztvBtm1XZ6H9DuswxKyxccicr2vc-DLYwZeZrWvffwWXoKq2TWOH0LXn6KSydfQX-3eBPh4f3pfPePX69LK8X2HHtBhwWpSAAkW414IJZdVaOuvKogIJ1fS3gmhfCVZ5r8vCaq2lZgUB7p2Qgi3Q9S5323c_o4-D2XRj36aRBjSjrOCU6ETlO8r1XYy9r8y2D43tfw0QM9kyky0z2TKTrdRwtY8d1-nQA_6vJwE3OyBubVuGsosHZorCDDDhmOgC2B_9zHJf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932354209</pqid></control><display><type>article</type><title>Piceatannol inhibits mast cell-mediated allergic inflammation</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>KO, YU-JIN ; KIM, HUI-HUN ; KIM, EUN-JUNG ; KATAKURA, YOSHINORI ; LEE, WON-SUP ; KIM, GON-SUP ; RYU, CHUNG-HO</creator><creatorcontrib>KO, YU-JIN ; KIM, HUI-HUN ; KIM, EUN-JUNG ; KATAKURA, YOSHINORI ; LEE, WON-SUP ; KIM, GON-SUP ; RYU, CHUNG-HO</creatorcontrib><description>Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro-inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2013.1283</identifier><identifier>PMID: 23426871</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>allergic inflammation ; Anaphylaxis ; Anaphylaxis - chemically induced ; Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; beta-N-Acetylhexosaminidases - metabolism ; Cell Line ; Cell Survival - drug effects ; cytokine ; Cytokines ; Cytokines - analysis ; Cytokines - genetics ; Cytokines - metabolism ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Gene expression ; Histamine - metabolism ; Humans ; Immunoglobulins ; Kinases ; Laboratory animals ; Leukemia ; Male ; MAP kinase ; mast cells ; Mast Cells - drug effects ; Mast Cells - metabolism ; Mice ; Mice, Inbred ICR ; Mortality ; p-Methoxy-N-methylphenethylamine - toxicity ; Penicillin ; Phosphorylation ; piceatannol ; Proteins ; Signal Transduction - drug effects ; Stilbenes - chemistry ; Stilbenes - pharmacology ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular medicine, 2013-04, Vol.31 (4), p.951-958</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-8920181804e96368a8b7cacd5f171f68a8a609ef63fee9d5a9997935014ec6763</citedby><cites>FETCH-LOGICAL-c396t-8920181804e96368a8b7cacd5f171f68a8a609ef63fee9d5a9997935014ec6763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23426871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KO, YU-JIN</creatorcontrib><creatorcontrib>KIM, HUI-HUN</creatorcontrib><creatorcontrib>KIM, EUN-JUNG</creatorcontrib><creatorcontrib>KATAKURA, YOSHINORI</creatorcontrib><creatorcontrib>LEE, WON-SUP</creatorcontrib><creatorcontrib>KIM, GON-SUP</creatorcontrib><creatorcontrib>RYU, CHUNG-HO</creatorcontrib><title>Piceatannol inhibits mast cell-mediated allergic inflammation</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro-inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.</description><subject>allergic inflammation</subject><subject>Anaphylaxis</subject><subject>Anaphylaxis - chemically induced</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>beta-N-Acetylhexosaminidases - metabolism</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Cytokines - analysis</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Gene expression</subject><subject>Histamine - metabolism</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Leukemia</subject><subject>Male</subject><subject>MAP kinase</subject><subject>mast cells</subject><subject>Mast Cells - drug effects</subject><subject>Mast Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Mortality</subject><subject>p-Methoxy-N-methylphenethylamine - toxicity</subject><subject>Penicillin</subject><subject>Phosphorylation</subject><subject>piceatannol</subject><subject>Proteins</subject><subject>Signal Transduction - drug effects</subject><subject>Stilbenes - chemistry</subject><subject>Stilbenes - pharmacology</subject><subject>Tumor necrosis factor-TNF</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo9kLtPwzAQhy0EoqWwMqJILCwOPtvxY2BAFS-pEgwgsVmu44CrPEqcDPz3OGrp5LP03e_uPoQugeRMaXobNk2TUwIsB6rYEZqD1IAp55_HqQYiMZOFmKGzGDeE0IJrdYpmlHEqlIQ5unsLztvBtm1XZ6H9DuswxKyxccicr2vc-DLYwZeZrWvffwWXoKq2TWOH0LXn6KSydfQX-3eBPh4f3pfPePX69LK8X2HHtBhwWpSAAkW414IJZdVaOuvKogIJ1fS3gmhfCVZ5r8vCaq2lZgUB7p2Qgi3Q9S5323c_o4-D2XRj36aRBjSjrOCU6ETlO8r1XYy9r8y2D43tfw0QM9kyky0z2TKTrdRwtY8d1-nQA_6vJwE3OyBubVuGsosHZorCDDDhmOgC2B_9zHJf</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>KO, YU-JIN</creator><creator>KIM, HUI-HUN</creator><creator>KIM, EUN-JUNG</creator><creator>KATAKURA, YOSHINORI</creator><creator>LEE, WON-SUP</creator><creator>KIM, GON-SUP</creator><creator>RYU, CHUNG-HO</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130401</creationdate><title>Piceatannol inhibits mast cell-mediated allergic inflammation</title><author>KO, YU-JIN ; KIM, HUI-HUN ; KIM, EUN-JUNG ; KATAKURA, YOSHINORI ; LEE, WON-SUP ; KIM, GON-SUP ; RYU, CHUNG-HO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-8920181804e96368a8b7cacd5f171f68a8a609ef63fee9d5a9997935014ec6763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>allergic inflammation</topic><topic>Anaphylaxis</topic><topic>Anaphylaxis - chemically induced</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>beta-N-Acetylhexosaminidases - metabolism</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Cytokines - analysis</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Gene expression</topic><topic>Histamine - metabolism</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Leukemia</topic><topic>Male</topic><topic>MAP kinase</topic><topic>mast cells</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Mortality</topic><topic>p-Methoxy-N-methylphenethylamine - toxicity</topic><topic>Penicillin</topic><topic>Phosphorylation</topic><topic>piceatannol</topic><topic>Proteins</topic><topic>Signal Transduction - drug effects</topic><topic>Stilbenes - chemistry</topic><topic>Stilbenes - pharmacology</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KO, YU-JIN</creatorcontrib><creatorcontrib>KIM, HUI-HUN</creatorcontrib><creatorcontrib>KIM, EUN-JUNG</creatorcontrib><creatorcontrib>KATAKURA, YOSHINORI</creatorcontrib><creatorcontrib>LEE, WON-SUP</creatorcontrib><creatorcontrib>KIM, GON-SUP</creatorcontrib><creatorcontrib>RYU, CHUNG-HO</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KO, YU-JIN</au><au>KIM, HUI-HUN</au><au>KIM, EUN-JUNG</au><au>KATAKURA, YOSHINORI</au><au>LEE, WON-SUP</au><au>KIM, GON-SUP</au><au>RYU, CHUNG-HO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piceatannol inhibits mast cell-mediated allergic inflammation</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>31</volume><issue>4</issue><spage>951</spage><epage>958</epage><pages>951-958</pages><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro-inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23426871</pmid><doi>10.3892/ijmm.2013.1283</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1107-3756 |
| ispartof | International journal of molecular medicine, 2013-04, Vol.31 (4), p.951-958 |
| issn | 1107-3756 1791-244X |
| language | eng |
| recordid | cdi_proquest_journals_1932354209 |
| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | allergic inflammation Anaphylaxis Anaphylaxis - chemically induced Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology beta-N-Acetylhexosaminidases - metabolism Cell Line Cell Survival - drug effects cytokine Cytokines Cytokines - analysis Cytokines - genetics Cytokines - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene expression Histamine - metabolism Humans Immunoglobulins Kinases Laboratory animals Leukemia Male MAP kinase mast cells Mast Cells - drug effects Mast Cells - metabolism Mice Mice, Inbred ICR Mortality p-Methoxy-N-methylphenethylamine - toxicity Penicillin Phosphorylation piceatannol Proteins Signal Transduction - drug effects Stilbenes - chemistry Stilbenes - pharmacology Tumor necrosis factor-TNF |
| title | Piceatannol inhibits mast cell-mediated allergic inflammation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T23%3A17%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Piceatannol%20inhibits%20mast%20cell-mediated%20allergic%20inflammation&rft.jtitle=International%20journal%20of%20molecular%20medicine&rft.au=KO,%20YU-JIN&rft.date=2013-04-01&rft.volume=31&rft.issue=4&rft.spage=951&rft.epage=958&rft.pages=951-958&rft.issn=1107-3756&rft.eissn=1791-244X&rft_id=info:doi/10.3892/ijmm.2013.1283&rft_dat=%3Cproquest_cross%3E1932354209%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932354209&rft_id=info:pmid/23426871&rfr_iscdi=true |