Inhibitory effects of STAT3 decoy oligodeoxynucleotides on human epithelial ovarian cancer cell growth in vivo

The signal transducer and activator of transcription 3 (STAT3) regulates target gene expression by binding to a consensus DNA sequence within the promoter of the target genes. The constitutive activation of STAT3 has been shown to contribute to tumorigenesis in ovarian cancer and it has been reporte...

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Veröffentlicht in:	International journal of molecular medicine 2013-09, Vol.32 (3), p.623-628
Hauptverfasser:	ZHANG, XIAOLEI, LIU, PEISHU, ZHANG, BO, MAO, HONGLUAN, SHEN, LIANG, MA, YANHUI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Apoptosis Apoptosis - drug effects Apoptosis - genetics Carcinoma, Ovarian Epithelial Caspase 3 - metabolism Cell Line, Tumor Cell Proliferation - drug effects decoy oligodeoxynucleotides Disease Models, Animal Female Humans in vivo Kidneys Kinases Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Oligodeoxyribonucleotides - pharmacology Oligodeoxyribonucleotides - toxicity Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - metabolism Rodents signal transducer and activator of transcription 3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Burden - drug effects Tumor Burden - genetics Xenograft Model Antitumor Assays
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