miR-96 functions as a tumor suppressor gene by targeting NUAK1 in pancreatic cancer

microRNA-96 (miR-96) is known to be downregulated in pancreatic cancer. The overexpression of miR-96 in MIA PaCa-2 pancreatic cancer cells has been shown to inhibit cell proliferation, migration and invasion; however, the mechanisms involved have not yet been fully elucidated. Novel (nua) kinase fam...

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Veröffentlicht in:	International journal of molecular medicine 2014-12, Vol.34 (6), p.1599-1605
Hauptverfasser:	HUANG, XUAN, LV, WEI, ZHANG, JIAN-HUA, LU, DA-LIN
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Adenosine Algorithms Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Breast cancer Cancer therapies Cell growth Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Gene expression Gene Expression Regulation, Neoplastic Gene Silencing Genes, Tumor Suppressor Genetic aspects Health aspects Hospitals Humans Kinases Medical prognosis Metastasis MicroRNA microRNA-96 MicroRNAs - genetics novel (nua) kinase family 1 Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Physiological aspects Plasmids Protein Kinases - genetics Protein Kinases - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Risk factors Tumor suppressor genes Tumorigenesis Up-Regulation
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