The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats

Status epilepticus (SE) causes neuronal loss and apoptosis by inducing several apoptosis-regulatory genes. Two such genes, cysteinyl aspartate-specific protease-3 (caspase-3), an apoptosis activator, and B-cell leukemia-2 (Bcl-2), an apoptosis suppressor, are tightly regulated for their expression a...

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Veröffentlicht in:	International journal of molecular medicine 2012-10, Vol.30 (4), p.739-746
Hauptverfasser:	SUN, JIAHANG, XIE, CHUNCHENG, LIU, WEI, LU, DUNYUE, QIAO, WEIDONG, HUANG, QI, HUO, ZHIHUI, SHEN, HONG, LIN, ZHIGUO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis B-cell leukemia-2 Caspase 3 - genetics Cholesterol cysteinyl aspartate-specific protease-3 Disease Drug dosages Epilepsy Ethanol Gene Expression Regulation - drug effects hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Kainic Acid Kinases Male Medical research Nervous system Neuroprotective Agents - pharmacology Protein expression Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Rats Rats, Wistar Rodents Seizures - chemically induced Seizures - drug therapy Seizures - pathology Signal transduction simvastatin Simvastatin - pharmacology Statins status epilepticus Status Epilepticus - chemically induced Status Epilepticus - drug therapy Status Epilepticus - pathology Studies Traumatic brain injury
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