Electroacupuncture at the Quchi and Zusanli acupoints exerts neuroprotective role in cerebral ischemia-reperfusion injured rats via activation of the PI3K/Akt pathway

The PI3K/Akt pathway, a critical mediator of cell survival, is suppressed in cerebral ischemia/reperfusion (I/R) injury; therefore, it is a major focus in treatment of ischemic stroke. Acupuncture has long been used in China to clinically treat stroke. However, the precise mechanism of its neuroprot...

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Veröffentlicht in:	International journal of molecular medicine 2012-10, Vol.30 (4), p.791-796
Hauptverfasser:	CHEN, AZHEN, LIN, ZHICHENG, LAN, LAN, XIE, GUANLI, HUANG, JIA, LIN, JIUMAO, PENG, JUN, TAO, JING, CHEN, LIDIAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Acupuncture Points Animals Apoptosis Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - therapy Brain-derived neurotrophic factor Carotid arteries cerebral ischemia/reperfusion Chinese medicine electroacupuncture Electroacupuncture - methods Ischemia Kinases Laboratory animals Male Medical research Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt pathway Proto-Oncogene Proteins c-akt - metabolism Quchi (LI11) acupoints Rats Rats, Sprague-Dawley Rehabilitation Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - therapy Rodents Signal Transduction Stroke Studies Veins & arteries Zusanli (ST36)
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