Ginsenoside Rg1 reduces aldosterone-induced autophagy via the AMPK/mTOR pathway in NRK-52E cells

Aldosterone is a steroid hormone secreted from the adrenal cortex, which regulates blood pressure. Higher concentrations of aldosterone can cause several diseases, including hypertension, diabetic nephropathy and chronic kidney disease. Previous reports have demonstrated that aldosterone has a patho...

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Veröffentlicht in:	International journal of molecular medicine 2015-08, Vol.36 (2), p.518-526
Hauptverfasser:	WANG, LI, MAO, NAN, TAN, RUI-ZHI, WANG, HONG-LIAN, WEN, JI, LIU, YU-HANG, FURHAD, MD, FAN, JUN-MING
Format:	Artikel
Sprache:	eng
Schlagworte:	aldosterone Aldosterone - metabolism AMP-Activated Protein Kinases - metabolism AMPK Animals Antioxidants Antioxidants - pharmacology Autophagy Autophagy - drug effects Cardiomyocytes Cell Line Cellular signal transduction Chinese medicine Drugs, Chinese Herbal - pharmacology ginsenoside Rg1 Ginsenosides - pharmacology Glycosides Health aspects Homeostasis Hypoxia Kidney Tubules - cytology Kidney Tubules - drug effects Kidney Tubules - metabolism Kidney Tubules - pathology Kinases Mammals NRK-52E cells Oxidative stress Oxidative Stress - drug effects Properties Proteins Rats Reactive Oxygen Species - metabolism Signal Transduction - drug effects Studies Substance abuse treatment TOR Serine-Threonine Kinases - metabolism Transmission electron microscopy
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