YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

YCG063 is known as an inhibitor of reactive oxygen species (ROS); however, its intracellular mechanisms of action remain poorly understood. In the present study, we investigated the effects of YCG063 on the inflammatory response of Pseudomonas aeruginosa lipopolysaccharide (PA-LPS)-stimulated human...

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Veröffentlicht in:	International journal of molecular medicine 2015-09, Vol.36 (3), p.808-816
Hauptverfasser:	PAENG, SUNG HWA, PARK, WON SUN, JUNG, WON-KYO, LEE, DAE-SUNG, KIM, GI-YOUNG, CHOI, YUNG HYUN, SEO, SU-KIL, JANG, WON HEE, CHOI, JUNG SIK, LEE, YOUNG-MIN, PARK, SAEGWANG, CHOI, IL-WHAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Anti-Inflammatory Agents - pharmacology Bacterial infections Care and treatment Cell culture Cell Line Cell Survival - drug effects Chemokines Cloning Cytokines Diabetic retinopathy endophthalmitis Enzyme-linked immunosorbent assay Gram-negative bacteria Health aspects Humans Hydrazones - pharmacology Immunoglobulins Inflammation Inflammation - drug therapy Inflammation - immunology Inflammation - microbiology Influence Kinases Lipopolysaccharides - immunology Neutrophils NF-kappa B - immunology Nitroimidazoles - pharmacology Nosocomial infections Phosphorylation Photoreceptors Physiological aspects Proto-Oncogene Proteins c-akt - immunology Pseudomonas aeruginosa Pseudomonas aeruginosa - immunology Reactive oxygen species Reactive Oxygen Species - immunology Retina retinal pigment epithelium Retinal Pigment Epithelium - cytology Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - immunology Retinal Pigment Epithelium - microbiology Risk factors Rodents Signal Transduction - drug effects Toll-like receptor Toll-Like Receptor 2 - immunology
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