Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway

High glucose levels can induce mesangial cell proliferation and extracellular matrix (ECM) accumulation through the type I activin receptor-like kinase 5 (ALK5) signaling pathway. Salt-inducible kinase 1 (SIK1) prevents fibrosis by downregulating ALK5, while the expression level of the SIK1 protein...

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Veröffentlicht in:	International journal of molecular medicine 2013-07, Vol.32 (1), p.151-157
Hauptverfasser:	YU, JIE, HU, XIAOPENG, YANG, ZHENGDONG, TAKEMORI, HIROSHI, LI, YANHONG, ZHENG, HUAN, HONG, SHICONG, LIAO, QIUHONG, WEN, XIUYING
Format:	Artikel
Sprache:	eng
Schlagworte:	activin receptor-like kinase 5 signaling pathway Animals Cell cycle Cell growth Cell Line Cell Proliferation Diabetes Extracellular Matrix - metabolism extracellular matrix accumulation Gene expression Gene Expression Regulation - drug effects Glucose Glucose - metabolism Glucose - pharmacology Kidney diseases Kinases Laboratories Mesangial Cells - drug effects Mesangial Cells - metabolism Metabolism Pathogenesis Polyclonal antibodies Protein expression Protein Transport - drug effects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Proteolysis Rats Receptors, Transforming Growth Factor beta - metabolism Rodents salt-inducible kinase 1 Signal Transduction - drug effects Studies
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