1,25-Dihydroxyvitamin D3 and cisplatin synergistically induce apoptosis and cell cycle arrest in gastric cancer cells

1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] plays an anticancer role in multiple types of cancer and potentiates the cytotoxic effects of several common chemotherapeutic agents. The hypercalcemia caused by 1,25(OH)2D3 alone or resistance to cisplatin weaken the anticancer effects of vitamin D. Thus, in t...

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Veröffentlicht in:	International journal of molecular medicine 2014-05, Vol.33 (5), p.1177-1184
Hauptverfasser:	BAO, ANYU, LI, YAN, TONG, YONGQING, ZHENG, HONGYUN, WU, WEI, WEI, CHUANDONG
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25-dihydroxyvitamin D3 Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Calcitriol - pharmacology Cancer therapies Caspase 3 - metabolism Caspase 8 - metabolism Cell cycle Cell Cycle Checkpoints - drug effects Cell growth Chemotherapy cisplatin Cisplatin - pharmacology Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin-Dependent Kinase Inhibitor p27 - metabolism Deoxyribonucleic acid DNA DNA damage Drug dosages Drug Synergism Gastric cancer Humans Poly(ADP-ribose) Polymerases - metabolism Stomach Neoplasms - metabolism Tumor Cells, Cultured Vitamin D
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