Role of metallothionein in murine experimental colitis

Metallothioneins (MTs) are a family of cysteine-rich low molecular-weight proteins that can act as reactive oxygen species scavengers. Although it is known that the induction of MT expression suppresses various inflammatory disorders, the role of MTs in intestinal inflammation remains unclear. In th...

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Veröffentlicht in:	International journal of molecular medicine 2013-05, Vol.31 (5), p.1037-1046
Hauptverfasser:	TSUJI, TOSHIFUMI, NAITO, YUJI, TAKAGI, TOMOHISA, KUGAI, MUNEHIRO, YORIKI, HIROYUKI, HORIE, RYUSUKE, FUKUI, AKIFUMI, MIZUSHIMA, KATSURA, HIRAI, YASUKO, KATADA, KAZUHIRO, KAMADA, KAZUHIRO, UCHIYAMA, KAZUHIKO, HANDA, OSAMU, KONISHI, HIDEYUKI, YAGI, NOBUAKI, ICHIKAWA, HIROSHI, YANAGISAWA, RIE, SUZUKI, JUNKO S, TAKANO, HIROHISA, SATOH, MASAHIKO, YOSHIKAWA, TOSHIKAZU
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Weight - drug effects Colitis - chemically induced Colitis - genetics Colitis - metabolism Colitis - pathology Colon Colon - pathology Cytokines Cytokines - genetics Cytokines - metabolism Dextran Sulfate dextran sulfate sodium Disease Enzyme-Linked Immunosorbent Assay Gene Expression Regulation - drug effects Immunohistochemistry Inflammation Inflammation - genetics Inflammation - pathology Inflammation Mediators - metabolism Inflammatory bowel disease intestinal inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Laboratory animals Lipopolysaccharides - pharmacology Localization macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Metallothionein - genetics Metallothionein - metabolism metallothioneins Mice Mice, Inbred C57BL Mice, Knockout Molecular weight Neutrophils - drug effects Neutrophils - metabolism Oxidative stress Pathogenesis Reactive oxygen species Reptiles & amphibians RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Studies Tumor necrosis factor-TNF
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