The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis

The present study aimed to analyze the responses to autophagy in osteoarthritis (OA) and aging chondrocytes in order to elucidate the role of autophagy in the pathogenesis of OA. We used multiple assays to confirm that autophagic activity was downregulated in chondrocytes of aged articular cartilage...

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Veröffentlicht in:	International journal of molecular medicine 2013-12, Vol.32 (6), p.1311-1318
Hauptverfasser:	CHANG, JUN, WANG, WEI, ZHANG, HUI, HU, YONG, WANG, MINGLI, YIN, ZONGSHENG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Aged Aging Apoptosis Apoptosis Regulatory Proteins - metabolism Arthritis Autophagy Autophagy - drug effects Beclin-1 Cartilage, Articular - metabolism Cartilage, Articular - pathology Cartilage, Articular - ultrastructure Cell Cycle - drug effects Cell Hypoxia - drug effects Cell Survival - drug effects Cells, Cultured chondrocyte Chondrocytes - metabolism Chondrocytes - pathology Chondrocytes - ultrastructure Disease Female Fractures Green Fluorescent Proteins - metabolism Humans Hypoxia Joint surgery Male Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Middle Aged osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Pathogenesis Proteins Sirolimus - pharmacology Studies Young Adult
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