Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix
Chrysanthemum zawadskii has been proven to possess hair growth activity and has been used as treatment for hair loss. The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair fo...
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| Veröffentlicht in: | International journal of molecular medicine 2014-07, Vol.34 (1), p.130-136 |
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| container_title | International journal of molecular medicine |
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| creator | LI, ZHENG LI, JINGJIE GU, LIJUAN BEGUM, SHAHNAZ WANG, YUNBO SUN, BAISHEN LEE, MIRA SUNG, CHANGKEUN |
| description | Chrysanthemum zawadskii has been proven to possess hair growth activity and has been used as treatment for hair loss. The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair follicle (HF) regions and the progression of growth. The n-butanol and water fractions of CZe were used for hair growth induction by topical application to the backs of C57BL/6 mice for up to 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections were detected using immunohistochemistry. The results showed that the water fraction of CZe promoted hair shaft production and induced premature entry of telogen HFs into the anagen. Subsequently, immunohistochemical studies indicated that the water fraction of CZe stimulated the differentiation and proliferation of pluripotent epidermal matrix cells in the matrix region and epithelial stem cells in the basal layer of the epidermis. Additionally, flavonoids were identified as effective constituents. Therefore, the findings of this study suggested that the water fraction of CZe may be developed as a therapeutic agent for the prevention of hair loss. |
| doi_str_mv | 10.3892/ijmm.2014.1768 |
| format | Article |
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The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair follicle (HF) regions and the progression of growth. The n-butanol and water fractions of CZe were used for hair growth induction by topical application to the backs of C57BL/6 mice for up to 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections were detected using immunohistochemistry. The results showed that the water fraction of CZe promoted hair shaft production and induced premature entry of telogen HFs into the anagen. Subsequently, immunohistochemical studies indicated that the water fraction of CZe stimulated the differentiation and proliferation of pluripotent epidermal matrix cells in the matrix region and epithelial stem cells in the basal layer of the epidermis. Additionally, flavonoids were identified as effective constituents. Therefore, the findings of this study suggested that the water fraction of CZe may be developed as a therapeutic agent for the prevention of hair loss.</description><identifier>ISSN: 1107-3756</identifier><identifier>EISSN: 1791-244X</identifier><identifier>DOI: 10.3892/ijmm.2014.1768</identifier><identifier>PMID: 24807783</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>1-Butanol ; Alopecia ; Animals ; Baldness ; Cell cycle ; Cell Differentiation - drug effects ; Cell growth ; Cell Proliferation - drug effects ; Cell Survival - drug effects ; Chrysanthemum - chemistry ; Chrysanthemum zawadskii ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - pharmacology ; Epidermis - cytology ; Epidermis - drug effects ; epithelial stem cell ; Female ; Flavonoids ; Hair ; Hair Follicle - cytology ; Hair Follicle - drug effects ; hair growth ; Health aspects ; Laboratory animals ; Materia medica, Vegetable ; Mice ; Mice, Inbred C57BL ; Plant extracts ; Pluripotent Stem Cells - cytology ; Pluripotent Stem Cells - drug effects ; Prevention ; proliferation ; Rodents ; Skin ; Solvents ; Stem cells ; Studies ; Water</subject><ispartof>International journal of molecular medicine, 2014-07, Vol.34 (1), p.130-136</ispartof><rights>Copyright © 2014, Spandidos Publications</rights><rights>COPYRIGHT 2014 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-44b4cb79ce1c162b130948489bbcdc6fae55168d42637726168d70318fbb0adc3</citedby><cites>FETCH-LOGICAL-c529t-44b4cb79ce1c162b130948489bbcdc6fae55168d42637726168d70318fbb0adc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24807783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LI, ZHENG</creatorcontrib><creatorcontrib>LI, JINGJIE</creatorcontrib><creatorcontrib>GU, LIJUAN</creatorcontrib><creatorcontrib>BEGUM, SHAHNAZ</creatorcontrib><creatorcontrib>WANG, YUNBO</creatorcontrib><creatorcontrib>SUN, BAISHEN</creatorcontrib><creatorcontrib>LEE, MIRA</creatorcontrib><creatorcontrib>SUNG, CHANGKEUN</creatorcontrib><title>Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix</title><title>International journal of molecular medicine</title><addtitle>Int J Mol Med</addtitle><description>Chrysanthemum zawadskii has been proven to possess hair growth activity and has been used as treatment for hair loss. The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair follicle (HF) regions and the progression of growth. The n-butanol and water fractions of CZe were used for hair growth induction by topical application to the backs of C57BL/6 mice for up to 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections were detected using immunohistochemistry. The results showed that the water fraction of CZe promoted hair shaft production and induced premature entry of telogen HFs into the anagen. Subsequently, immunohistochemical studies indicated that the water fraction of CZe stimulated the differentiation and proliferation of pluripotent epidermal matrix cells in the matrix region and epithelial stem cells in the basal layer of the epidermis. Additionally, flavonoids were identified as effective constituents. Therefore, the findings of this study suggested that the water fraction of CZe may be developed as a therapeutic agent for the prevention of hair loss.</description><subject>1-Butanol</subject><subject>Alopecia</subject><subject>Animals</subject><subject>Baldness</subject><subject>Cell cycle</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell growth</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Chrysanthemum - chemistry</subject><subject>Chrysanthemum zawadskii</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Epidermis - cytology</subject><subject>Epidermis - drug effects</subject><subject>epithelial stem cell</subject><subject>Female</subject><subject>Flavonoids</subject><subject>Hair</subject><subject>Hair Follicle - cytology</subject><subject>Hair Follicle - drug effects</subject><subject>hair growth</subject><subject>Health aspects</subject><subject>Laboratory animals</subject><subject>Materia medica, Vegetable</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Plant extracts</subject><subject>Pluripotent Stem Cells - cytology</subject><subject>Pluripotent Stem Cells - drug effects</subject><subject>Prevention</subject><subject>proliferation</subject><subject>Rodents</subject><subject>Skin</subject><subject>Solvents</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Water</subject><issn>1107-3756</issn><issn>1791-244X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkcuLFDEQxoMo7kOvHiXgxUuPeXUnfVyGVRcWvCh4C3nOZJykxyTN7PjXm2bW9bIkkErx-6oq-QB4h9GKipF8CrsYVwRhtsJ8EC_AJeYj7ghjP1-2GCPeUd4PF-CqlB1CpGejeA0uCBOIc0EvwXG9zaeiUt26OEf4Rx2VLb9CgO6hZmUqDMnOxhW4VSHDTZ6OdQv1CZYa4rxXNaQNbFp4yNM-eJdbZkpQJQtt8O3uUg3n3OTPNaKqOTy8Aa-82hf39vG8Bj8-335ff-3uv325W9_cd6YnY-0Y08xoPhqHDR6IxhSNTDAxam2sGbxyfY8HYRkZKOdkWGKOKBZea6Ssodfgw7luG_D37EqVu2nOqbWUeKSEMiQE_k9t1N7JkPy0PD6GYuQNoxyh1rNv1OoZqi3rYjBTcj60_HMCk6dSsvPykENU-SQxkot9crFPLvbJxb4meP847ayjs0_4P78a8PEMlEP742Cn8sQspTrKOoTbpoj-BepqpKs</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>LI, ZHENG</creator><creator>LI, JINGJIE</creator><creator>GU, LIJUAN</creator><creator>BEGUM, SHAHNAZ</creator><creator>WANG, YUNBO</creator><creator>SUN, BAISHEN</creator><creator>LEE, MIRA</creator><creator>SUNG, CHANGKEUN</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140701</creationdate><title>Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix</title><author>LI, ZHENG ; LI, JINGJIE ; GU, LIJUAN ; BEGUM, SHAHNAZ ; WANG, YUNBO ; SUN, BAISHEN ; LEE, MIRA ; SUNG, CHANGKEUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-44b4cb79ce1c162b130948489bbcdc6fae55168d42637726168d70318fbb0adc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>1-Butanol</topic><topic>Alopecia</topic><topic>Animals</topic><topic>Baldness</topic><topic>Cell cycle</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell growth</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Chrysanthemum - chemistry</topic><topic>Chrysanthemum zawadskii</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Epidermis - cytology</topic><topic>Epidermis - drug effects</topic><topic>epithelial stem cell</topic><topic>Female</topic><topic>Flavonoids</topic><topic>Hair</topic><topic>Hair Follicle - cytology</topic><topic>Hair Follicle - drug effects</topic><topic>hair growth</topic><topic>Health aspects</topic><topic>Laboratory animals</topic><topic>Materia medica, Vegetable</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Plant extracts</topic><topic>Pluripotent Stem Cells - cytology</topic><topic>Pluripotent Stem Cells - drug effects</topic><topic>Prevention</topic><topic>proliferation</topic><topic>Rodents</topic><topic>Skin</topic><topic>Solvents</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LI, ZHENG</creatorcontrib><creatorcontrib>LI, JINGJIE</creatorcontrib><creatorcontrib>GU, LIJUAN</creatorcontrib><creatorcontrib>BEGUM, SHAHNAZ</creatorcontrib><creatorcontrib>WANG, YUNBO</creatorcontrib><creatorcontrib>SUN, BAISHEN</creatorcontrib><creatorcontrib>LEE, MIRA</creatorcontrib><creatorcontrib>SUNG, CHANGKEUN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LI, ZHENG</au><au>LI, JINGJIE</au><au>GU, LIJUAN</au><au>BEGUM, SHAHNAZ</au><au>WANG, YUNBO</au><au>SUN, BAISHEN</au><au>LEE, MIRA</au><au>SUNG, CHANGKEUN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>34</volume><issue>1</issue><spage>130</spage><epage>136</epage><pages>130-136</pages><issn>1107-3756</issn><eissn>1791-244X</eissn><abstract>Chrysanthemum zawadskii has been proven to possess hair growth activity and has been used as treatment for hair loss. The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair follicle (HF) regions and the progression of growth. The n-butanol and water fractions of CZe were used for hair growth induction by topical application to the backs of C57BL/6 mice for up to 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections were detected using immunohistochemistry. The results showed that the water fraction of CZe promoted hair shaft production and induced premature entry of telogen HFs into the anagen. Subsequently, immunohistochemical studies indicated that the water fraction of CZe stimulated the differentiation and proliferation of pluripotent epidermal matrix cells in the matrix region and epithelial stem cells in the basal layer of the epidermis. Additionally, flavonoids were identified as effective constituents. Therefore, the findings of this study suggested that the water fraction of CZe may be developed as a therapeutic agent for the prevention of hair loss.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24807783</pmid><doi>10.3892/ijmm.2014.1768</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | 1-Butanol Alopecia Animals Baldness Cell cycle Cell Differentiation - drug effects Cell growth Cell Proliferation - drug effects Cell Survival - drug effects Chrysanthemum - chemistry Chrysanthemum zawadskii Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Epidermis - cytology Epidermis - drug effects epithelial stem cell Female Flavonoids Hair Hair Follicle - cytology Hair Follicle - drug effects hair growth Health aspects Laboratory animals Materia medica, Vegetable Mice Mice, Inbred C57BL Plant extracts Pluripotent Stem Cells - cytology Pluripotent Stem Cells - drug effects Prevention proliferation Rodents Skin Solvents Stem cells Studies Water |
| title | Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix |
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