Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2

The high proliferative rate of tumor cells leads to metabolic needs distinct from those of their normal counterparts. An embryonic- and tumor-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is overexpressed in cancer cells to increase the use of glycolytic intermediates for macromolecular b...

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Veröffentlicht in:	International journal of molecular medicine 2012-08, Vol.30 (2), p.302-308
Hauptverfasser:	JIANG, KAI, HE, BAOMING, LAI, LIHUA, CHEN, QINGYUN, LIU, YANG, GUO, QINGMING, WANG, QINGQING
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Breast cancer breast cancer cells Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chemotherapy Cyclosporine - pharmacology cyclosporine A Down-Regulation Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Enzymes Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Kinases Metabolism Metabolites Mitochondria Pyruvate Kinase - genetics Pyruvate Kinase - metabolism pyruvate kinase M2
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