The phytogestrogenic stilbenes, arachidin-1 and resveratrol, modulate regulatory T cell functions responsible for successful aging in aged ICR mice

CD4+CD25+ regulatory T cells (Tregs) are recognized as a distinctive T helper cell population which controls immunosuppression during the maintenance of immunological self-tolerance and immunohomeostasis. Sex steroids modulate fundamental immune functions, including immune cell development, differen...

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Veröffentlicht in:	International journal of molecular medicine 2016-12, Vol.38 (6), p.1895-1904
Hauptverfasser:	Weng, Brian Bor-Chun, Lin, Wen-Shin, Chang, Ju-Chun, Chiou, Robin Yih-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Aging - drug effects Aging - physiology Analysis Animals arachidin-1 Biomarkers Centenarians Cytokines - metabolism cytotoxic T lymphocyte-associated antigen 4 Cytotoxicity Dendritic cells Dietary Supplements Female Gene expression Immunophenotyping Kinases Laboratory animals Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocytes Metabolites Mice Mice, Inbred ICR nuclear transcription factor forkhead box P3 Oldest old people Phenotype phytoestrogen regulatory T cells Resveratrol Rodents Stilbenes - pharmacology T cells T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - physiology Tamoxifen - pharmacology Tumor necrosis factor-TNF
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