HIF-1α is a crucial factor in the development of peritoneal dissemination via natural metastatic routes in scirrhous gastric cancer

The molecular mechanisms underlying the peritoneal dissemination of gastric cancer remain unclear. Using in vivo metastatic models, this study attempted to clarify the role of hypoxia inducible factor (HIF)-1α in the development of peritoneal dissemination of gastric cancer. HIF-1α knockdown (KD) ce...

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Veröffentlicht in:	International journal of oncology 2013-11, Vol.43 (5), p.1431-1440
Hauptverfasser:	Miyake, Shuusuke, Kitajima, Yoshihiko, Nakamura, Jun, Kai, Keita, Yanagihara, Kazuyoshi, Tanaka, Tomokazu, Hiraki, Masatsugu, Miyazaki, Kohji, Noshiro, Hirokazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Scirrhous - genetics Adenocarcinoma, Scirrhous - metabolism Adenocarcinoma, Scirrhous - pathology Angiogenesis Animals Apoptosis Blotting, Western Cell Adhesion Cell Proliferation Female Gastric cancer Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Immunoenzyme Techniques Immunoglobulins Metastasis Mice Mice, Inbred BALB C Mice, Nude Neovascularization, Pathologic Peritoneal Neoplasms - genetics Peritoneal Neoplasms - metabolism Peritoneal Neoplasms - secondary Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Studies Tumors
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