Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia

Hyperthermia can transiently degrade BRCA2 and thereby inhibit the homologous recombination pathway. Induced DNA-double strand breaks (DSB) then have to be repaired via the error prone non-homologous end-joining pathway. In the present study, to investigate the role of hyperthermia in genotoxicity a...

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Veröffentlicht in:	International journal of molecular medicine 2016-07, Vol.38 (1), p.243-250
Hauptverfasser:	BERGS, JUDITH W.J, OEI, ARLENE L, CATE, ROSEMARIE TEN, RODERMOND, HANS M, STALPERS, LUKAS J, BARENDSEN, GERRIT W, FRANKEN, NICOLAAS A.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - radiation effects Blotting, Western BRCA mutations BRCA2 Protein - metabolism Cell Line, Tumor cell survival Cell Survival - radiation effects Chromatids - metabolism chromosomal fragments chromosomal translocations Chromosome Aberrations Chromosome abnormalities Clone Cells Deoxyribonucleic acid Development and progression DNA DNA damage Dose-Response Relationship, Radiation Drug resistance Fever Genetic aspects Health aspects Humans Hyperthermia Hyperthermia, Induced Influence linear quadratic-model premature chromosome condensation and fluorescence in situ hybridisation Proteins Proteolysis Radiation Tolerance Radiation, Ionizing Studies Translocation, Genetic - radiation effects Tumor Suppressor Protein p53 - metabolism
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