CAPE promotes TRAIL-induced apoptosis through the upregulation of TRAIL receptors via activation of p38 and suppression of JNK in SK-Hep1 hepatocellular carcinoma cells

Caffeic acid phenethyl ester (CAPE), a phenolic compound derived from honeybee propolis, has been reported to possess anticancer activities in several types of malignant cells. Here, we show that treatment with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in combination with CAPE...

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Veröffentlicht in:	International journal of oncology 2013-10, Vol.43 (4), p.1291-1300
Hauptverfasser:	KIM, EUN YOUNG, RYU, JAE-HA, KIM, AN KEUN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Bees - chemistry caffeic acid phenethyl ester Caffeic Acids - administration & dosage Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor combination Gene Expression Regulation, Neoplastic - drug effects hepatoma Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology MAP Kinase Kinase 4 - biosynthesis MAP Kinase Kinase 4 - genetics p38 Mitogen-Activated Protein Kinases - biosynthesis p38 Mitogen-Activated Protein Kinases - genetics Phenylethyl Alcohol - administration & dosage Phenylethyl Alcohol - analogs & derivatives Propolis - administration & dosage Propolis - chemistry Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Rodents Signal Transduction - drug effects Studies TNF-Related Apoptosis-Inducing Ligand - genetics tumor necrosis factor-related apoptosis-inducing ligand Tumor necrosis factor-TNF Up-Regulation - drug effects
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