Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner

Tumor cells express NKG2D ligands on their cell surface, which are the ligands of the activating receptor, NKG2D, that is expressed on the surface of NK cells. The binding of NK cells to tumor cells through the interaction of NKG2D and its ligands induces the cytolysis of the tumor cells. In the pre...

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Veröffentlicht in:	International journal of oncology 2012-12, Vol.41 (6), p.2005-2012
Hauptverfasser:	YAMADA, NAOKO, YAMANEGI, KOJI, OHYAMA, HIDEKI, HATA, MASAKI, NAKASHO, KEIJI, FUTANI, HIROYUKI, OKAMURA, HARUKI, TERADA, NOBUYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bone cancer Cell culture Cell Hypoxia Cell Line, Tumor Cell Proliferation Chemotherapy Cytotoxicity Cytotoxicity, Immunologic - immunology Diseases of the osteoarticular system Down-Regulation - genetics Flow cytometry Gene Expression Regulation, Neoplastic Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism hypoxia-inducing factor-1α Killer Cells, Natural - immunology Ligands Lymphocytes Medical sciences Metastasis MHC class I-related chain molecule Nitric Oxide NK Cell Lectin-Like Receptor Subfamily K - metabolism osteosarcoma Osteosarcoma - genetics Osteosarcoma - immunology Osteosarcoma - metabolism Proteins Rodents Sarcoma soluble MHC class I-related chain molecule A Studies Tumors Tumors of striated muscle and skeleton
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