Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance

Pancreatic cancer stem cells play a crucial role in tumorigenesis and chemoresistance. The Hedgehog signaling pathway is a key regulator in pancreatic tumorigenesis and drug resistance. To identify pancreatic cancer stem cells, tumorspheres derived from the PANC-1 pancreatic cancer cell line were cu...

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Veröffentlicht in:	International journal of oncology 2012-11, Vol.41 (5), p.1707-1714
Hauptverfasser:	HUANG, FENG-TING, ZHUAN-SUN, YONG-XUN, ZHUANG, YAN-YAN, WEI, SHU-LI, TANG, JIAN, CHEN, WEN-BO, ZHANG, SHI-NENG
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 AC133 Antigen Animals Antigens, CD - genetics Antigens, CD - metabolism Bmi-1 Brain cancer cancer stem cell Cell cycle Cell Differentiation Cell Line, Tumor Cell Proliferation - drug effects Cell Transformation, Neoplastic - metabolism Chemotherapy Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Glycoproteins - genetics Glycoproteins - metabolism Hedgehog Proteins - genetics Hedgehog Proteins - metabolism hedgehog signaling pathway Humans Ligands Lymphoma Mice Mice, Inbred NOD Mice, SCID Morphology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Penicillin Peptides - genetics Peptides - metabolism Prostate Proteins Rodents Signal transduction Signal Transduction - drug effects Spheres Spheroids, Cellular Stem cells Transcription factors Tumor Cells, Cultured Tumorigenesis Tumors tumorsphere Veratrum Alkaloids - pharmacology
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