Identification of Akt1 as a potent therapeutic target for oral squamous cell carcinoma

Oncogene addiction can provide therapeutic opportunities in human malignancies. In this study, we aimed to identify critical oncogenes for oral squamous cell carcinoma (OSCC) development and progression. We determined gene expression profiles in 10 primary OSCCs and 10 human OSCC cell lines using Ap...

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Veröffentlicht in:	International journal of oncology 2015-10, Vol.47 (4), p.1273-1281
Hauptverfasser:	NAKASHIRO, KOH-ICHI, TANAKA, HIROSHI, GODA, HIROYUKI, IWAMOTO, KAZUKI, TOKUZEN, NORIHIKO, HARA, SHINGO, ONODERA, JUN, FUJIMOTO, ICHIRO, HINO, SATOSHI, HAMAKAWA, HIROYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Akt1 Analysis Animals Blotting, Western Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Care and treatment Cell division Chemotherapy Cytokines Female Gene expression Genetic aspects Genomes Growth factors Health aspects Heterografts Humans Identification and classification Immunohistochemistry Kinases Male Medical prognosis Metastasis Mice Mice, Nude molecular target therapy Mortality Mouth cancer Mouth Neoplasms - genetics Mouth Neoplasms - pathology Mutation Oligonucleotide Array Sequence Analysis Oncogenes Oral cancer oral squamous cell carcinoma Patients Phosphatase Polymerase Chain Reaction Proteins Proto-Oncogene Proteins c-akt - genetics Radiation therapy RNA, Small Interfering Rodents Software Squamous cell carcinoma Transfection Tumors
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