Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells

The MET tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), are known to be over-expressed in a variety of malignant tumor cells, and are implicated in the development of gefitinib-resistance in human non-small cell lung cancer (NSCLC) cells. Ephedrae herba was previously report...

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Veröffentlicht in:	International journal of oncology 2016-05, Vol.48 (5), p.1895-1906
Hauptverfasser:	NISHIMURA, YUKIO, HYUGA, SUMIKO, TAKIGUCHI, SOICHI, HYUGA, MASASHI, ITOH, KAZUYUKI, HANAWA, TOSHIHIKO
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Breast cancer Carcinoma, Non-Small-Cell Lung - metabolism Care and treatment Cell Line, Tumor Down-Regulation - drug effects Drug Resistance, Neoplasm - drug effects endocytosis Endocytosis - drug effects endosomes/lysosomes Ephedra Ephedra - chemistry Ephedrae herba Gene amplification Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genetic regulation Growth factors Health aspects hepatocyte growth factor Hepatocyte Growth Factor - metabolism Humans Immunoglobulins Inhibitor drugs Kinases Ligands Lung cancer Lung cancer, Non-small cell Lung Neoplasms - metabolism Materia medica, Vegetable MET Metastasis Microscopy Motility non-small cell lung cancer p-MET Phosphorylation Phosphorylation - drug effects Plant extracts Plant Extracts - pharmacology Properties Protein expression Proteins Proto-Oncogene Proteins c-met - metabolism Quinazolines - pharmacology Signal Transduction - drug effects Studies Targeted cancer therapy
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