Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma
Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly...
Gespeichert in:
| Veröffentlicht in: | International journal of oncology 2015-02, Vol.46 (2), p.782-790 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 790 |
|---|---|
| container_issue | 2 |
| container_start_page | 782 |
| container_title | International journal of oncology |
| container_volume | 46 |
| creator | FANG, QIN-LIANG YIN, YI-RUI XIE, CHENG-RONG ZHANG, SHENG ZHAO, WEN-XIU PAN, CHAO WANG, XIAO-MIN YIN, ZHEN-YU |
| description | Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly understood. In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the DNA methyltransferase 1 (DNMT1) via an AKT/β-transducin repeat-containing protein (βTrCP)-mediated ubiquitin-proteasome pathway in HCC. Analysis of DNA methylation in CpG islands of target genes revealed high co-localization of DNMT1 and DNMT3B on the promoters of TSGs associated with enhanced CpG hypermethylation. Our results point to a novel epigenetic mechanism for growth factor-mediated repression of TSG transcription that involves DNA methylation. |
| doi_str_mv | 10.3892/ijo.2014.2776 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1932331373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A401381482</galeid><sourcerecordid>A401381482</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-6304534498493c10c1e518aa38097a798455184089d551a5f97cfb1bdae1afe73</originalsourceid><addsrcrecordid>eNptkc2LFDEQxRtR3HX16FUCgp56zFdPd47D-gmrXvTc1KQr3RnSSZukkbn6l5th1tUFCSQvxe9VUbyqes7oRnSKv7GHsOGUyQ1v2-2D6pK1itVccvGwaMpUvZVCXVRPUjpQypuGssfVBW8kp1Kpy-rXZ9QTeJuy1QT8QPY2uDBaDY4kO3privQaSTDk7ZcdmTFPR5cj-GQwQkLCyLpEHFcHGYv9SMYYfuaJGNA5xESsJ9M6Q7lxgRw0OlfYSDREbX2Y4Wn1yIBL-Oz2vaq-v3_37fpjffP1w6fr3U2tpaK53goqGyGl6qQSmlHNsGEdgOioaqEt5ab8Je3UUAQ0RrXa7Nl-AGRgsBVX1ctz3yWGHyum3B_CGn0Z2TMluBBMtOIvNYLD3noTyrJ6tkn3O0mZ6JjseKE2_6HKGXC2Ong0ttTvGV79Y5gQXJ5ScGu2waf7YH0GdQwpRTT9Eu0M8dgz2p8S70vi_Snx_pR44V_cbrXuZxzu6D8RF-D1GUhLydcOId0xpVMttzXlNW3L6N-XorJv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932331373</pqid></control><display><type>article</type><title>Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>FANG, QIN-LIANG ; YIN, YI-RUI ; XIE, CHENG-RONG ; ZHANG, SHENG ; ZHAO, WEN-XIU ; PAN, CHAO ; WANG, XIAO-MIN ; YIN, ZHEN-YU</creator><creatorcontrib>FANG, QIN-LIANG ; YIN, YI-RUI ; XIE, CHENG-RONG ; ZHANG, SHENG ; ZHAO, WEN-XIU ; PAN, CHAO ; WANG, XIAO-MIN ; YIN, ZHEN-YU</creatorcontrib><description>Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly understood. In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the DNA methyltransferase 1 (DNMT1) via an AKT/β-transducin repeat-containing protein (βTrCP)-mediated ubiquitin-proteasome pathway in HCC. Analysis of DNA methylation in CpG islands of target genes revealed high co-localization of DNMT1 and DNMT3B on the promoters of TSGs associated with enhanced CpG hypermethylation. Our results point to a novel epigenetic mechanism for growth factor-mediated repression of TSG transcription that involves DNA methylation.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2014.2776</identifier><identifier>PMID: 25420499</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Apoptosis ; Cancer therapies ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - pathology ; Cell cycle ; Cell growth ; CpG Islands ; Deoxyribonucleic acid ; Development and progression ; DNA ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases - biosynthesis ; DNA (Cytosine-5-)-Methyltransferases - genetics ; DNA methylation ; DNA Methylation - drug effects ; DNA methyltransferase 1 ; DNA Methyltransferase 3B ; Epigenesis, Genetic - drug effects ; Epigenetics ; Experiments ; Gene Expression Regulation, Neoplastic - drug effects ; Gene Targeting ; Genes ; Genetic aspects ; Genomes ; Growth factors ; Hep G2 Cells ; hepatocellular carcinoma ; Hepatoma ; Humans ; Insulin-like growth factor 1 ; Intercellular Signaling Peptides and Proteins - administration & dosage ; Kinases ; Liver cancer ; Liver Neoplasms - drug therapy ; Liver Neoplasms - genetics ; Liver Neoplasms - pathology ; Lung cancer ; Medical prognosis ; Methyltransferases ; Mice ; Neoplasm Proteins - biosynthesis ; Phosphorylation ; Physiological aspects ; Promoter Regions, Genetic ; Proteins ; Tumorigenesis ; Xenograft Model Antitumor Assays</subject><ispartof>International journal of oncology, 2015-02, Vol.46 (2), p.782-790</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-6304534498493c10c1e518aa38097a798455184089d551a5f97cfb1bdae1afe73</citedby><cites>FETCH-LOGICAL-c490t-6304534498493c10c1e518aa38097a798455184089d551a5f97cfb1bdae1afe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,5556,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25420499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FANG, QIN-LIANG</creatorcontrib><creatorcontrib>YIN, YI-RUI</creatorcontrib><creatorcontrib>XIE, CHENG-RONG</creatorcontrib><creatorcontrib>ZHANG, SHENG</creatorcontrib><creatorcontrib>ZHAO, WEN-XIU</creatorcontrib><creatorcontrib>PAN, CHAO</creatorcontrib><creatorcontrib>WANG, XIAO-MIN</creatorcontrib><creatorcontrib>YIN, ZHEN-YU</creatorcontrib><title>Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly understood. In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the DNA methyltransferase 1 (DNMT1) via an AKT/β-transducin repeat-containing protein (βTrCP)-mediated ubiquitin-proteasome pathway in HCC. Analysis of DNA methylation in CpG islands of target genes revealed high co-localization of DNMT1 and DNMT3B on the promoters of TSGs associated with enhanced CpG hypermethylation. Our results point to a novel epigenetic mechanism for growth factor-mediated repression of TSG transcription that involves DNA methylation.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>CpG Islands</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>DNA (Cytosine-5-)-Methyltransferase 1</subject><subject>DNA (Cytosine-5-)-Methyltransferases - biosynthesis</subject><subject>DNA (Cytosine-5-)-Methyltransferases - genetics</subject><subject>DNA methylation</subject><subject>DNA Methylation - drug effects</subject><subject>DNA methyltransferase 1</subject><subject>DNA Methyltransferase 3B</subject><subject>Epigenesis, Genetic - drug effects</subject><subject>Epigenetics</subject><subject>Experiments</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Gene Targeting</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Growth factors</subject><subject>Hep G2 Cells</subject><subject>hepatocellular carcinoma</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Insulin-like growth factor 1</subject><subject>Intercellular Signaling Peptides and Proteins - administration & dosage</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - pathology</subject><subject>Lung cancer</subject><subject>Medical prognosis</subject><subject>Methyltransferases</subject><subject>Mice</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>Tumorigenesis</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkc2LFDEQxRtR3HX16FUCgp56zFdPd47D-gmrXvTc1KQr3RnSSZukkbn6l5th1tUFCSQvxe9VUbyqes7oRnSKv7GHsOGUyQ1v2-2D6pK1itVccvGwaMpUvZVCXVRPUjpQypuGssfVBW8kp1Kpy-rXZ9QTeJuy1QT8QPY2uDBaDY4kO3privQaSTDk7ZcdmTFPR5cj-GQwQkLCyLpEHFcHGYv9SMYYfuaJGNA5xESsJ9M6Q7lxgRw0OlfYSDREbX2Y4Wn1yIBL-Oz2vaq-v3_37fpjffP1w6fr3U2tpaK53goqGyGl6qQSmlHNsGEdgOioaqEt5ab8Je3UUAQ0RrXa7Nl-AGRgsBVX1ctz3yWGHyum3B_CGn0Z2TMluBBMtOIvNYLD3noTyrJ6tkn3O0mZ6JjseKE2_6HKGXC2Ong0ttTvGV79Y5gQXJ5ScGu2waf7YH0GdQwpRTT9Eu0M8dgz2p8S70vi_Snx_pR44V_cbrXuZxzu6D8RF-D1GUhLydcOId0xpVMttzXlNW3L6N-XorJv</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>FANG, QIN-LIANG</creator><creator>YIN, YI-RUI</creator><creator>XIE, CHENG-RONG</creator><creator>ZHANG, SHENG</creator><creator>ZHAO, WEN-XIU</creator><creator>PAN, CHAO</creator><creator>WANG, XIAO-MIN</creator><creator>YIN, ZHEN-YU</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20150201</creationdate><title>Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma</title><author>FANG, QIN-LIANG ; YIN, YI-RUI ; XIE, CHENG-RONG ; ZHANG, SHENG ; ZHAO, WEN-XIU ; PAN, CHAO ; WANG, XIAO-MIN ; YIN, ZHEN-YU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-6304534498493c10c1e518aa38097a798455184089d551a5f97cfb1bdae1afe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell cycle</topic><topic>Cell growth</topic><topic>CpG Islands</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>DNA (Cytosine-5-)-Methyltransferase 1</topic><topic>DNA (Cytosine-5-)-Methyltransferases - biosynthesis</topic><topic>DNA (Cytosine-5-)-Methyltransferases - genetics</topic><topic>DNA methylation</topic><topic>DNA Methylation - drug effects</topic><topic>DNA methyltransferase 1</topic><topic>DNA Methyltransferase 3B</topic><topic>Epigenesis, Genetic - drug effects</topic><topic>Epigenetics</topic><topic>Experiments</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Gene Targeting</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Growth factors</topic><topic>Hep G2 Cells</topic><topic>hepatocellular carcinoma</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Insulin-like growth factor 1</topic><topic>Intercellular Signaling Peptides and Proteins - administration & dosage</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - pathology</topic><topic>Lung cancer</topic><topic>Medical prognosis</topic><topic>Methyltransferases</topic><topic>Mice</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Phosphorylation</topic><topic>Physiological aspects</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>Tumorigenesis</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FANG, QIN-LIANG</creatorcontrib><creatorcontrib>YIN, YI-RUI</creatorcontrib><creatorcontrib>XIE, CHENG-RONG</creatorcontrib><creatorcontrib>ZHANG, SHENG</creatorcontrib><creatorcontrib>ZHAO, WEN-XIU</creatorcontrib><creatorcontrib>PAN, CHAO</creatorcontrib><creatorcontrib>WANG, XIAO-MIN</creatorcontrib><creatorcontrib>YIN, ZHEN-YU</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FANG, QIN-LIANG</au><au>YIN, YI-RUI</au><au>XIE, CHENG-RONG</au><au>ZHANG, SHENG</au><au>ZHAO, WEN-XIU</au><au>PAN, CHAO</au><au>WANG, XIAO-MIN</au><au>YIN, ZHEN-YU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>46</volume><issue>2</issue><spage>782</spage><epage>790</epage><pages>782-790</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly understood. In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the DNA methyltransferase 1 (DNMT1) via an AKT/β-transducin repeat-containing protein (βTrCP)-mediated ubiquitin-proteasome pathway in HCC. Analysis of DNA methylation in CpG islands of target genes revealed high co-localization of DNMT1 and DNMT3B on the promoters of TSGs associated with enhanced CpG hypermethylation. Our results point to a novel epigenetic mechanism for growth factor-mediated repression of TSG transcription that involves DNA methylation.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25420499</pmid><doi>10.3892/ijo.2014.2776</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1019-6439 |
| ispartof | International journal of oncology, 2015-02, Vol.46 (2), p.782-790 |
| issn | 1019-6439 1791-2423 |
| language | eng |
| recordid | cdi_proquest_journals_1932331373 |
| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell cycle Cell growth CpG Islands Deoxyribonucleic acid Development and progression DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - biosynthesis DNA (Cytosine-5-)-Methyltransferases - genetics DNA methylation DNA Methylation - drug effects DNA methyltransferase 1 DNA Methyltransferase 3B Epigenesis, Genetic - drug effects Epigenetics Experiments Gene Expression Regulation, Neoplastic - drug effects Gene Targeting Genes Genetic aspects Genomes Growth factors Hep G2 Cells hepatocellular carcinoma Hepatoma Humans Insulin-like growth factor 1 Intercellular Signaling Peptides and Proteins - administration & dosage Kinases Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Lung cancer Medical prognosis Methyltransferases Mice Neoplasm Proteins - biosynthesis Phosphorylation Physiological aspects Promoter Regions, Genetic Proteins Tumorigenesis Xenograft Model Antitumor Assays |
| title | Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T05%3A58%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanistic%20and%20biological%20significance%20of%20DNA%20methyltransferase%201%20upregulated%20by%20growth%20factors%20in%20human%20hepatocellular%20carcinoma&rft.jtitle=International%20journal%20of%20oncology&rft.au=FANG,%20QIN-LIANG&rft.date=2015-02-01&rft.volume=46&rft.issue=2&rft.spage=782&rft.epage=790&rft.pages=782-790&rft.issn=1019-6439&rft.eissn=1791-2423&rft_id=info:doi/10.3892/ijo.2014.2776&rft_dat=%3Cgale_proqu%3EA401381482%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932331373&rft_id=info:pmid/25420499&rft_galeid=A401381482&rfr_iscdi=true |