MALDI TOF imaging mass spectrometry in clinical pathology: A valuable tool for cancer diagnostics (Review)
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the advantages of mass spectrometry (proteomics), detection of numerous molecules, and spatial resolution in histological tissue sectio...
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| Veröffentlicht in: | International journal of oncology 2015-03, Vol.46 (3), p.893-906 |
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| container_title | International journal of oncology |
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| creator | KRIEGSMANN, JÖRG KRIEGSMANN, MARK CASADONTE, RITA |
| description | Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the advantages of mass spectrometry (proteomics), detection of numerous molecules, and spatial resolution in histological tissue sections and cytological preparations. This method allows the detection of proteins, peptides, lipids, carbohydrates or glycoconjugates and small molecules. Formalin-fixed paraffin-embedded tissue can also be investigated by IMS, thus, this method seems to be an ideal tool for cancer diagnostics and biomarker discovery. It may add information to the identification of tumor margins and tumor heterogeneity. The technique allows tumor typing, especially identification of the tumor of origin in metastatic tissue, as well as grading and may provide prognostic information. IMS is a valuable method for the identification of biomarkers and can complement histology, immunohistology and molecular pathology in various fields of histopathological diagnostics, especially with regard to identification and grading of tumors. |
| doi_str_mv | 10.3892/ijo.2014.2788 |
| format | Article |
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This method allows the detection of proteins, peptides, lipids, carbohydrates or glycoconjugates and small molecules. Formalin-fixed paraffin-embedded tissue can also be investigated by IMS, thus, this method seems to be an ideal tool for cancer diagnostics and biomarker discovery. It may add information to the identification of tumor margins and tumor heterogeneity. The technique allows tumor typing, especially identification of the tumor of origin in metastatic tissue, as well as grading and may provide prognostic information. 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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biomarkers, Tumor - analysis Brain - metabolism Cancer Diagnosis Freezing Humans imaging mass spectrometry Immunohistochemistry - methods Ions Kinases MALDI molecular pathology Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - pathology Ovarian cancer Paraffin Embedding pathology Pathology, Clinical - methods Prognosis Proteins - analysis Skin cancer Specimen Handling - methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Time-of-flight mass spectrometry Tissue Array Analysis Tissue Fixation - methods |
| title | MALDI TOF imaging mass spectrometry in clinical pathology: A valuable tool for cancer diagnostics (Review) |
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