Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways
Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrest...
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| Veröffentlicht in: | International journal of oncology 2015-04, Vol.46 (4), p.1739-1747 |
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| container_title | International journal of oncology |
| container_volume | 46 |
| creator | WANG, GUANGXIU DAI, FANG YU, KAI JIA, ZHIFAN ZHANG, ANLING HUANG, QIANG KANG, CHUNSHENG JIANG, HAO PU, PEIYU |
| description | Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas. |
| doi_str_mv | 10.3892/ijo.2015.2863 |
| format | Article |
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In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2015.2863</identifier><identifier>PMID: 25646654</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis ; Brain cancer ; Brain Neoplasms - drug therapy ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Cancer therapies ; Cell cycle ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cellular signal transduction ; Clinical trials ; Dosage and administration ; Down-Regulation ; Drug therapy ; Glioma ; Glioma - drug therapy ; Glioma - genetics ; Glioma - metabolism ; Gliomas ; Health aspects ; Metastasis ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Proteins ; Radiation therapy ; Rats ; Resveratrol ; Signal Transduction - drug effects ; Stilbenes - administration & dosage ; Stilbenes - pharmacology ; Studies ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>International journal of oncology, 2015-04, Vol.46 (4), p.1739-1747</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-b26c7bfed3ba94d21abccec6356ea20f890e3b20f784687f5fde2ac93baf23dc3</citedby><cites>FETCH-LOGICAL-c490t-b26c7bfed3ba94d21abccec6356ea20f890e3b20f784687f5fde2ac93baf23dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,5570,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25646654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, GUANGXIU</creatorcontrib><creatorcontrib>DAI, FANG</creatorcontrib><creatorcontrib>YU, KAI</creatorcontrib><creatorcontrib>JIA, ZHIFAN</creatorcontrib><creatorcontrib>ZHANG, ANLING</creatorcontrib><creatorcontrib>HUANG, QIANG</creatorcontrib><creatorcontrib>KANG, CHUNSHENG</creatorcontrib><creatorcontrib>JIANG, HAO</creatorcontrib><creatorcontrib>PU, PEIYU</creatorcontrib><title>Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Resveratrol (Res), a natural polyphenolic compound, has anticancer activity in a variety of cancers. In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis</subject><subject>Brain cancer</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - metabolism</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cellular signal transduction</subject><subject>Clinical trials</subject><subject>Dosage and administration</subject><subject>Down-Regulation</subject><subject>Drug therapy</subject><subject>Glioma</subject><subject>Glioma - drug therapy</subject><subject>Glioma - genetics</subject><subject>Glioma - metabolism</subject><subject>Gliomas</subject><subject>Health aspects</subject><subject>Metastasis</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Rats</subject><subject>Resveratrol</subject><subject>Signal Transduction - drug effects</subject><subject>Stilbenes - administration & dosage</subject><subject>Stilbenes - pharmacology</subject><subject>Studies</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0d9r1TAUB_AiipvTR18lIOhTr_nVtHm8DH_BUBj6HNL0tM0lTWqSbuy_N5c7pwPJQ0L4nENOvlX1muAd6yT9YA9hRzFpdrQT7El1TlpJasope1rOmMhacCbPqhcpHTCmTYPJ8-qMNoIL0fDzyl5DuoGocwwOWT_b3uaEJmfDopEB59AUw22e0Y3VKOs4QbZ-QsGbMIG3Bi3WxHD9bZ-Q9gNaNpft6gAlO3ntjnTVeb7Vd-ll9WzULsGr-_2i-vnp44_LL_XV989fL_dXteES57qnwrT9CAPrteQDJbo3BoxgjQBN8dhJDKwvh7bjomvHZhyAaiMLHykbDLuo3p76rjH82iBldQhbLI9JikhGGSNEsL9q0g6U9WPIUZvFJqP2HEvciZaKonb_UWUNUOYOHkZb7h8VvPunYAbt8pyC27INPj2G9QmW30spwqjWaBcd7xTB6hisKsGqY7DqGGzxb-6n2voFhgf9J8kC3p9AWksQdgjpwZRONRc15jVpmWS_AZFQq_k</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>WANG, GUANGXIU</creator><creator>DAI, FANG</creator><creator>YU, KAI</creator><creator>JIA, ZHIFAN</creator><creator>ZHANG, ANLING</creator><creator>HUANG, QIANG</creator><creator>KANG, CHUNSHENG</creator><creator>JIANG, HAO</creator><creator>PU, PEIYU</creator><general>D.A. 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In the present study, the antitumor effect and underlying molecular mechanism of Res on rat C6 glioma growth was studied. The results demonstrated that Res inhibited glioma cell proliferation, arrested cell cycle in S phase and induced apoptosis in vitro. Res also suppressed intracranial C6 tumor growth in vivo and prolonged survival in a fraction of the rats bearing intracranial gliomas. Res significantltly downregulated the specific miRs, including miR-21, miR-30a-5p and miR-19, which have been identified as oncomiRs in our previous studies, and altered the expression of their targeting and crucial genes for glioma formation and progression such as p53, PTEN, EGFR, STAT3, COX-2, NF-κB and PI3K/AKT/mTOR pathway. Therefore, the anti-glioma effect of Res, at least in part, is through the regulation of oncogenic miRNAs. The effect of Res on non-coding RNAs should be studied further. Res is a potential multi-targeting drug for the treatment of gliomas.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25646654</pmid><doi>10.3892/ijo.2015.2863</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of oncology, 2015-04, Vol.46 (4), p.1739-1747 |
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| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Cellular signal transduction Clinical trials Dosage and administration Down-Regulation Drug therapy Glioma Glioma - drug therapy Glioma - genetics Glioma - metabolism Gliomas Health aspects Metastasis MicroRNA MicroRNAs MicroRNAs - genetics Proteins Radiation therapy Rats Resveratrol Signal Transduction - drug effects Stilbenes - administration & dosage Stilbenes - pharmacology Studies Tumors Xenograft Model Antitumor Assays |
| title | Resveratrol inhibits glioma cell growth via targeting oncogenic microRNAs and multiple signaling pathways |
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