EGF-stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib-resistant human lung cancer cell line

The receptor tyrosine kinase epidermal growth factor receptor (EGFR) and its ligand epidermal growth factor (EGF) are known to play important roles in malignant tumor cells, and the EGFR signaling pathway is one of the most important targets in various tumors, including non-small cell lung cancer (N...

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Veröffentlicht in:	International journal of oncology 2015-04, Vol.46 (4), p.1721-1729
Hauptverfasser:	NISHIMURA, YUKIO, TAKIGUCHI, SOICHI, ITO, SHIGERU, ITOH, KAZUYUKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell culture Cell Line, Tumor Cell Membrane - metabolism Development and progression Drug Resistance, Neoplasm EGFR recycling endocytosis Endocytosis - drug effects endosomes/lysosomes Epidermal growth factor Epidermal Growth Factor - pharmacology epidermal growth factor receptor gefitinib Gene Knockdown Techniques Health aspects Humans Inhibitor drugs Kinases Ligands Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Membranes MET Monensin - pharmacology non-small cell lung cancer Phosphorylation Phosphorylation - drug effects Plasma Protein Kinase Inhibitors - pharmacology Protein kinases Proto-Oncogene Proteins c-akt - metabolism Quinazolines - pharmacology Receptor, Epidermal Growth Factor - metabolism Recycling Rodents serine/threonine kinase AKT Signal transduction Signal Transduction - drug effects sorting nexin 1 Sorting Nexins - genetics Sorting Nexins - metabolism Tumors
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