Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells

The ubiquitin-proteasome system (UPS) is one of the most promising anticancer drug targets of the century. However, the involved molecular mechanisms are still unclear. The nonsense-mediated mRNA decay (NMD) pathway is a highly conserved pathway which degrades nonsense mutation-containing mRNA selec...

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Veröffentlicht in:	International journal of oncology 2014-01, Vol.44 (1), p.222-228
Hauptverfasser:	ZHAO, XIA, NOGAWA, ATSUSHI, MATSUNAGA, TSUKASA, TAKEGAMI, TSUTOMU, NAKAGAWA, HIDEAKI, ISHIGAKI, YASUHITO
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - pharmacology Androstadienes - pharmacology Antimitotic agents Antineoplastic agents Cancer Cell cycle Cycloheximide - pharmacology Drug therapy Exons Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Health aspects Humans Immunoglobulins Kinases Mental disorders Mutation nonsense mediated mRNA decay Nonsense Mediated mRNA Decay - drug effects Nonsense Mediated mRNA Decay - genetics Phosphatidylinositol 3-Kinases - genetics Phosphorylation - drug effects Physiological aspects Polypeptides proteasome Proteasome Inhibitors - pharmacology Proteins RNA Helicases RNA, Small Interfering - genetics Signal transduction SMG1 Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factors - biosynthesis Transcription Factors - genetics ubiquitin Ubiquitin - metabolism Ubiquitin-proteasome system Upf1 Upf2 Wortmannin
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