Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition

Epithelial-mesenchymal transition (EMT) has recently been studied to elucidate mechanisms of the liver metastatic process. We investigated EMT in the process of liver metastasis and the effects of chemotherapy on EMT cells as therapeutic strategy for colorectal liver metastasis. We used the CT26 mur...

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Veröffentlicht in:	International journal of oncology 2013-02, Vol.42 (2), p.556-564
Hauptverfasser:	TANAHASHI, TOSHIYUKI, OSADA, SHINJI, YAMADA, ATSUKO, KATO, JUNKO, YAWATA, KAZUNORI, MORI, RYUTARO, IMAI, HISASHI, SASAKI, YOSHIYUKI, SAITO, SHIRO, TANAKA, YOSHIHIRO, NONAKA, KENICHI, YOSHIDA, KAZUHIRO
Format:	Artikel
Sprache:	eng
Schlagworte:	5-FU Animals c-Met Cancer therapies Cell growth Chemotherapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - genetics ERK/Akt pathway Growth factors hepatocyte growth factor Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Immunoglobulins Kinases Laboratory animals liver Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - secondary Medical prognosis Metastasis Mice Mitogen-Activated Protein Kinase 3 - genetics Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Oncogene Protein v-akt - genetics Oncogene Protein v-akt - metabolism Proteins Proto-Oncogene Proteins c-met - genetics Rodents Signal Transduction Smad Proteins - genetics Stem cells Transcriptional Activation - genetics Transforming Growth Factor beta - genetics transforming growth factor-β
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