Targeting the effector domain of the myristoylated alanine rich C-kinase substrate enhances lung cancer radiation sensitivity

Lung cancer is the leading cause of cancer related deaths. Common molecular drivers of lung cancer are mutations in receptor tyrosine kinases (RTKs) leading to activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pro-growth, pro-survival signaling pathways. Myristoylated alanine rich C-kinase...

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Veröffentlicht in:	International journal of oncology 2015-03, Vol.46 (3), p.1079-1088
Hauptverfasser:	ROHRBACH, TIMOTHY D, JARBOE, JOHN S, ANDERSON, JOSHUA C, TRUMMELL, HOA Q, HICKS, PATRICIA H, WEAVER, ALICE N, YANG, EDDY S, OSTER, ROBERT A, DESHANE, JESSY S, STEELE, CHAD, SIEGAL, GENE P, BONNER, JAMES A, WILLEY, CHRISTOPHER D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - pathology Adenocarcinoma of Lung Amino Acid Sequence Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Care and treatment Cell Line, Tumor - drug effects Cell Line, Tumor - radiation effects Cloning DNA Repair - genetics Ethanol Female Gene expression Growth factors Health aspects Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kinases Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - radiotherapy Male MARCKS Medical prognosis Membrane Proteins - genetics Membrane Proteins - metabolism Middle Aged Molecular Mimicry Molecular Sequence Data Molecular Targeted Therapy - methods Mutation Myristoylated Alanine-Rich C Kinase Substrate Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - pharmacology Phosphatase Phosphorylation Physiological aspects Plasmids Protein expression Protein kinases Protein Structure, Tertiary Proteins radiation therapy Radiation Tolerance Radiation, Ionizing Radiotherapy Squamous cell carcinoma Tissue Array Analysis
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