miR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells

Immune evasion of cancer cells is mainly due to the impaired transduction of apoptotic signals from immune cells to cancer cells, as well as inhibition of subsequent apoptosis signal cascades within the cancer cells. Over the past few decades, the research has focused more on the impaired transducti...

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Veröffentlicht in:	International journal of oncology 2015-03, Vol.46 (3), p.1169-1180
Hauptverfasser:	FU, BIN, WANG, YIBING, ZHANG, XIALI, LANG, BIN, ZHOU, XIAOCHENG, XU, XIAOYUAN, ZENG, TAO, LIU, WEIPENG, ZHANG, XU, GUO, JU, WANG, GONGXIAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Apoptosis Regulatory Proteins - genetics bcl-2-Associated X Protein - genetics Binding sites Bladder cancer Cell Proliferation - drug effects Cellular proteins Cellular signal transduction Development and progression Extracellular matrix Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Genetic aspects Health aspects Humans immune escape Immune response Metastasis MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - physiology miR-221 Neoplasm Invasiveness Oligoribonucleotides, Antisense - genetics Oligoribonucleotides, Antisense - pharmacology Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 - genetics Regulation RNA Interference - drug effects RNA Interference - physiology Signal transduction Studies Tumor Cells, Cultured Tumor Escape - genetics Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - pathology Vascular endothelial growth factor
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