Differential expression of CXCR4 and CXCR7 with various stem cell markers in paired human primary and recurrent glioblastomas

The chemokine CXCL12 (also termed SDF-1, stromal cell-derived factor-1) and its receptors CXCR4 and CXCR7 are known to play a pivotal role in tumor progression including glioblastomas (GBM). Previous investigations focused on the expression and functional roles of CXCR4 and CXCR7 in different GBM ce...

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Veröffentlicht in:	International journal of oncology 2016-04, Vol.48 (4), p.1408-1416
Hauptverfasser:	FLÜH, CHARLOTTE, HATTERMANN, KIRSTEN, MEHDORN, H. MAXIMILIAN, SYNOWITZ, MICHAEL, HELD-FEINDT, JANKA
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Brain cancer Cell Proliferation - genetics Cellular proteins Chemokines CXCR4 CXCR7 Development and progression Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glioblastoma - genetics Glioblastoma - pathology Glioblastoma multiforme glioblastomas Health aspects Humans Immunoglobulins Innovations Kruppel-Like Transcription Factors - biosynthesis Kruppel-Like Transcription Factors - genetics Male Medical prognosis Molecular targeted therapy Nanog Homeobox Protein - biosynthesis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Octamer Transcription Factor-3 - biosynthesis primary Properties Receptors, CXCR - biosynthesis Receptors, CXCR - genetics Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - genetics recurrent SOXB1 Transcription Factors - biosynthesis Stem cells Tumors
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