Picrasma quassiodes (D. Don) Benn. attenuates lipopolysaccharide (LPS)-induced acute lung injury

Picrasma quassiodes (D.Don) Benn. (PQ) is a medicinal herb belonging to the family Simaroubaceae and is used as a traditional herbal remedy for various diseases. In this study, we evaluated the effects of PQ on airway inflammation using a mouse model of lipopolysaccharide (LPS)-induced acute lung in...

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Veröffentlicht in:	International journal of molecular medicine 2016-09, Vol.38 (3), p.834-844
Hauptverfasser:	Lee, Jae-Won, Park, Ji-Won, Shin, Na-Rae, Park, So-Yeon, Kwon, Ok-Kyoung, Park, Hyun Ah, Lim, Yourim, Ryu, Hyung Won, Yuk, Heung Joo, Kim, Jung Hee, Oh, Sei-Ryang, Ahn, Kyung-Seop
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects acute lung injury Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - prevention & control Administration, Intranasal Animals Blotting, Western Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Cell Line Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cytokines Cytokines - metabolism Gene Expression - drug effects heme oxygenase-1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism inducible nitric oxide synthase Inflammation Mediators - metabolism Kinases Laboratory animals Lipopolysaccharides - administration & dosage Lipopolysaccharides - toxicity Lung - drug effects Lung - metabolism Lung - pathology Lungs Male Mice, Inbred C57BL mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism Neutrophils NF-kappa B - metabolism Nitric Oxide Synthase Type II - metabolism nuclear factor-κB Phosphorylation Phytotherapy - methods Picrasma - chemistry Picrasma quassiodes (D. Don) Benn Plant Extracts - pharmacology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents Tumor necrosis factor-TNF
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