PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements
The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. The PAX8 gene gives rise to four isofo...
Gespeichert in:
| Veröffentlicht in: | International journal of oncology 2016-07, Vol.49 (1), p.371-380 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 380 |
|---|---|
| container_issue | 1 |
| container_start_page | 371 |
| container_title | International journal of oncology |
| container_volume | 49 |
| creator | LÓPEZ-URRUTIA, EDUARDO PEDROZA-TORRES, ABRAHAM FERNÁNDEZ-RETANA, JORGE DE LEON, DAVID CANTU MORALES-GONZÁLEZ, FERMÍN JACOBO-HERRERA, NADIA PERALTA-ZARAGOZA, OSCAR GARCÍA-MENDEZ, JORGE GARCÍA-CASTILLO, VERÓNICA BAUTISTA-ISIDRO, OSVALDO PÉREZ-PLASENCIA, CARLOS |
| description | The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. The PAX8 gene gives rise to four isoforms, through alternative mRNA splicing, but the splicing pattern in tumors is not yet established. Cervical cancer has a positive expression of PAX8; however, there is no available data determining which PAX8 isoform or isoforms are present in cervical cancer tissues as well as in cervical carcinoma-derived cell lines. Instead of a differential pattern of splicing isoforms, we found numerous previously unreported PAX8 aberrant transcripts ranging from 378 to 542 bases and present in both cervical carcinoma-derived cell lines and tumor samples. This is the first report of PAX8 aberrant transcript production in cervical cancer. Reported PAX8 isoforms possess differential transactivation properties; therefore, besides being a helpful marker for detection of cancer, PAX8 isoforms can plausibly exert differential regulation properties during carcinogenesis. |
| doi_str_mv | 10.3892/ijo.2016.3515 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_1932325980</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A457330681</galeid><sourcerecordid>A457330681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c490t-39f7377b47a67828a79d6525cde0361b53aed73e59e02cc4bb2d50c81c0fd44e3</originalsourceid><addsrcrecordid>eNptkctrFTEUh4NY7EOXbiUg2NVc85hMJstLqVUo1IWCu5BJztzmmkmuyUxp_3tzubVakCzy4Du_cM6H0FtKVrxX7KPfphUjtFtxQcULdEKlog1rGX9Zz4Sqpmu5OkanpWwJYUIQ-godM0mlkH1_gn5-Xf_osS94ziYWm_0ADpsBcr3O4QH7iC3kO29NwPMypVywiQ47yP6ukhZCwMFHKNgtgOeEbZp2Ae7xBiLgDGYftIEJ4lxeo6PRhAJvHvcz9P3T5beLz831zdWXi_V1Y1tF5oarUXIph1aaTvasN1K5TjBhHRDe0UFwA05yEAoIs7YdBuYEsT21ZHRtC_wMvT_k7nL6tUCZ9TYtOdYvNVWccSZUT_5SGxNA-zimOgI7-WL1uhWSc9L1tFKr_1B1OZi8TRFGX9-fFXz4p-AWTJhvSwrL7FMsz8HmANqcSskw6l32k8kPmhK9V6urWr1Xq_dqK__usatlmMA90X9cVuD8AJRdVeRdKk9MTWpa1RDaEC4p_w1Q8Ko4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932325980</pqid></control><display><type>article</type><title>PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>LÓPEZ-URRUTIA, EDUARDO ; PEDROZA-TORRES, ABRAHAM ; FERNÁNDEZ-RETANA, JORGE ; DE LEON, DAVID CANTU ; MORALES-GONZÁLEZ, FERMÍN ; JACOBO-HERRERA, NADIA ; PERALTA-ZARAGOZA, OSCAR ; GARCÍA-MENDEZ, JORGE ; GARCÍA-CASTILLO, VERÓNICA ; BAUTISTA-ISIDRO, OSVALDO ; PÉREZ-PLASENCIA, CARLOS</creator><creatorcontrib>LÓPEZ-URRUTIA, EDUARDO ; PEDROZA-TORRES, ABRAHAM ; FERNÁNDEZ-RETANA, JORGE ; DE LEON, DAVID CANTU ; MORALES-GONZÁLEZ, FERMÍN ; JACOBO-HERRERA, NADIA ; PERALTA-ZARAGOZA, OSCAR ; GARCÍA-MENDEZ, JORGE ; GARCÍA-CASTILLO, VERÓNICA ; BAUTISTA-ISIDRO, OSVALDO ; PÉREZ-PLASENCIA, CARLOS</creatorcontrib><description>The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. The PAX8 gene gives rise to four isoforms, through alternative mRNA splicing, but the splicing pattern in tumors is not yet established. Cervical cancer has a positive expression of PAX8; however, there is no available data determining which PAX8 isoform or isoforms are present in cervical cancer tissues as well as in cervical carcinoma-derived cell lines. Instead of a differential pattern of splicing isoforms, we found numerous previously unreported PAX8 aberrant transcripts ranging from 378 to 542 bases and present in both cervical carcinoma-derived cell lines and tumor samples. This is the first report of PAX8 aberrant transcript production in cervical cancer. Reported PAX8 isoforms possess differential transactivation properties; therefore, besides being a helpful marker for detection of cancer, PAX8 isoforms can plausibly exert differential regulation properties during carcinogenesis.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2016.3515</identifier><identifier>PMID: 27175788</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Alternative Splicing - genetics ; Binding sites ; Biopsy ; Carcinogenesis - genetics ; Cell growth ; Cell Line, Tumor ; Cervical cancer ; Deoxyribonucleic acid ; Development and progression ; DNA ; Experiments ; Female ; Gene expression ; Gene Expression Regulation, Neoplastic ; gene rearrangement ; Gene Rearrangement - genetics ; Genetic aspects ; Health aspects ; Human papillomavirus ; Humans ; Ovarian cancer ; PAX8 ; PAX8 Transcription Factor - biosynthesis ; PAX8 Transcription Factor - genetics ; Properties ; Protein Isoforms - biosynthesis ; Protein Isoforms - genetics ; RNA, Messenger - biosynthesis ; Studies ; Thyroid gland ; Transcription factors ; Tumors ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - pathology</subject><ispartof>International journal of oncology, 2016-07, Vol.49 (1), p.371-380</ispartof><rights>Copyright © 2016, Spandidos Publications</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-39f7377b47a67828a79d6525cde0361b53aed73e59e02cc4bb2d50c81c0fd44e3</citedby><cites>FETCH-LOGICAL-c490t-39f7377b47a67828a79d6525cde0361b53aed73e59e02cc4bb2d50c81c0fd44e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5555,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27175788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LÓPEZ-URRUTIA, EDUARDO</creatorcontrib><creatorcontrib>PEDROZA-TORRES, ABRAHAM</creatorcontrib><creatorcontrib>FERNÁNDEZ-RETANA, JORGE</creatorcontrib><creatorcontrib>DE LEON, DAVID CANTU</creatorcontrib><creatorcontrib>MORALES-GONZÁLEZ, FERMÍN</creatorcontrib><creatorcontrib>JACOBO-HERRERA, NADIA</creatorcontrib><creatorcontrib>PERALTA-ZARAGOZA, OSCAR</creatorcontrib><creatorcontrib>GARCÍA-MENDEZ, JORGE</creatorcontrib><creatorcontrib>GARCÍA-CASTILLO, VERÓNICA</creatorcontrib><creatorcontrib>BAUTISTA-ISIDRO, OSVALDO</creatorcontrib><creatorcontrib>PÉREZ-PLASENCIA, CARLOS</creatorcontrib><title>PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. The PAX8 gene gives rise to four isoforms, through alternative mRNA splicing, but the splicing pattern in tumors is not yet established. Cervical cancer has a positive expression of PAX8; however, there is no available data determining which PAX8 isoform or isoforms are present in cervical cancer tissues as well as in cervical carcinoma-derived cell lines. Instead of a differential pattern of splicing isoforms, we found numerous previously unreported PAX8 aberrant transcripts ranging from 378 to 542 bases and present in both cervical carcinoma-derived cell lines and tumor samples. This is the first report of PAX8 aberrant transcript production in cervical cancer. Reported PAX8 isoforms possess differential transactivation properties; therefore, besides being a helpful marker for detection of cancer, PAX8 isoforms can plausibly exert differential regulation properties during carcinogenesis.</description><subject>Alternative Splicing - genetics</subject><subject>Binding sites</subject><subject>Biopsy</subject><subject>Carcinogenesis - genetics</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cervical cancer</subject><subject>Deoxyribonucleic acid</subject><subject>Development and progression</subject><subject>DNA</subject><subject>Experiments</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>gene rearrangement</subject><subject>Gene Rearrangement - genetics</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Ovarian cancer</subject><subject>PAX8</subject><subject>PAX8 Transcription Factor - biosynthesis</subject><subject>PAX8 Transcription Factor - genetics</subject><subject>Properties</subject><subject>Protein Isoforms - biosynthesis</subject><subject>Protein Isoforms - genetics</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Studies</subject><subject>Thyroid gland</subject><subject>Transcription factors</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkctrFTEUh4NY7EOXbiUg2NVc85hMJstLqVUo1IWCu5BJztzmmkmuyUxp_3tzubVakCzy4Du_cM6H0FtKVrxX7KPfphUjtFtxQcULdEKlog1rGX9Zz4Sqpmu5OkanpWwJYUIQ-godM0mlkH1_gn5-Xf_osS94ziYWm_0ADpsBcr3O4QH7iC3kO29NwPMypVywiQ47yP6ukhZCwMFHKNgtgOeEbZp2Ae7xBiLgDGYftIEJ4lxeo6PRhAJvHvcz9P3T5beLz831zdWXi_V1Y1tF5oarUXIph1aaTvasN1K5TjBhHRDe0UFwA05yEAoIs7YdBuYEsT21ZHRtC_wMvT_k7nL6tUCZ9TYtOdYvNVWccSZUT_5SGxNA-zimOgI7-WL1uhWSc9L1tFKr_1B1OZi8TRFGX9-fFXz4p-AWTJhvSwrL7FMsz8HmANqcSskw6l32k8kPmhK9V6urWr1Xq_dqK__usatlmMA90X9cVuD8AJRdVeRdKk9MTWpa1RDaEC4p_w1Q8Ko4</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>LÓPEZ-URRUTIA, EDUARDO</creator><creator>PEDROZA-TORRES, ABRAHAM</creator><creator>FERNÁNDEZ-RETANA, JORGE</creator><creator>DE LEON, DAVID CANTU</creator><creator>MORALES-GONZÁLEZ, FERMÍN</creator><creator>JACOBO-HERRERA, NADIA</creator><creator>PERALTA-ZARAGOZA, OSCAR</creator><creator>GARCÍA-MENDEZ, JORGE</creator><creator>GARCÍA-CASTILLO, VERÓNICA</creator><creator>BAUTISTA-ISIDRO, OSVALDO</creator><creator>PÉREZ-PLASENCIA, CARLOS</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20160701</creationdate><title>PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements</title><author>LÓPEZ-URRUTIA, EDUARDO ; PEDROZA-TORRES, ABRAHAM ; FERNÁNDEZ-RETANA, JORGE ; DE LEON, DAVID CANTU ; MORALES-GONZÁLEZ, FERMÍN ; JACOBO-HERRERA, NADIA ; PERALTA-ZARAGOZA, OSCAR ; GARCÍA-MENDEZ, JORGE ; GARCÍA-CASTILLO, VERÓNICA ; BAUTISTA-ISIDRO, OSVALDO ; PÉREZ-PLASENCIA, CARLOS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-39f7377b47a67828a79d6525cde0361b53aed73e59e02cc4bb2d50c81c0fd44e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alternative Splicing - genetics</topic><topic>Binding sites</topic><topic>Biopsy</topic><topic>Carcinogenesis - genetics</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cervical cancer</topic><topic>Deoxyribonucleic acid</topic><topic>Development and progression</topic><topic>DNA</topic><topic>Experiments</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>gene rearrangement</topic><topic>Gene Rearrangement - genetics</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Ovarian cancer</topic><topic>PAX8</topic><topic>PAX8 Transcription Factor - biosynthesis</topic><topic>PAX8 Transcription Factor - genetics</topic><topic>Properties</topic><topic>Protein Isoforms - biosynthesis</topic><topic>Protein Isoforms - genetics</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Studies</topic><topic>Thyroid gland</topic><topic>Transcription factors</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LÓPEZ-URRUTIA, EDUARDO</creatorcontrib><creatorcontrib>PEDROZA-TORRES, ABRAHAM</creatorcontrib><creatorcontrib>FERNÁNDEZ-RETANA, JORGE</creatorcontrib><creatorcontrib>DE LEON, DAVID CANTU</creatorcontrib><creatorcontrib>MORALES-GONZÁLEZ, FERMÍN</creatorcontrib><creatorcontrib>JACOBO-HERRERA, NADIA</creatorcontrib><creatorcontrib>PERALTA-ZARAGOZA, OSCAR</creatorcontrib><creatorcontrib>GARCÍA-MENDEZ, JORGE</creatorcontrib><creatorcontrib>GARCÍA-CASTILLO, VERÓNICA</creatorcontrib><creatorcontrib>BAUTISTA-ISIDRO, OSVALDO</creatorcontrib><creatorcontrib>PÉREZ-PLASENCIA, CARLOS</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LÓPEZ-URRUTIA, EDUARDO</au><au>PEDROZA-TORRES, ABRAHAM</au><au>FERNÁNDEZ-RETANA, JORGE</au><au>DE LEON, DAVID CANTU</au><au>MORALES-GONZÁLEZ, FERMÍN</au><au>JACOBO-HERRERA, NADIA</au><au>PERALTA-ZARAGOZA, OSCAR</au><au>GARCÍA-MENDEZ, JORGE</au><au>GARCÍA-CASTILLO, VERÓNICA</au><au>BAUTISTA-ISIDRO, OSVALDO</au><au>PÉREZ-PLASENCIA, CARLOS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>49</volume><issue>1</issue><spage>371</spage><epage>380</epage><pages>371-380</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. The PAX8 gene gives rise to four isoforms, through alternative mRNA splicing, but the splicing pattern in tumors is not yet established. Cervical cancer has a positive expression of PAX8; however, there is no available data determining which PAX8 isoform or isoforms are present in cervical cancer tissues as well as in cervical carcinoma-derived cell lines. Instead of a differential pattern of splicing isoforms, we found numerous previously unreported PAX8 aberrant transcripts ranging from 378 to 542 bases and present in both cervical carcinoma-derived cell lines and tumor samples. This is the first report of PAX8 aberrant transcript production in cervical cancer. Reported PAX8 isoforms possess differential transactivation properties; therefore, besides being a helpful marker for detection of cancer, PAX8 isoforms can plausibly exert differential regulation properties during carcinogenesis.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>27175788</pmid><doi>10.3892/ijo.2016.3515</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1019-6439 |
| ispartof | International journal of oncology, 2016-07, Vol.49 (1), p.371-380 |
| issn | 1019-6439 1791-2423 |
| language | eng |
| recordid | cdi_proquest_journals_1932325980 |
| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alternative Splicing - genetics Binding sites Biopsy Carcinogenesis - genetics Cell growth Cell Line, Tumor Cervical cancer Deoxyribonucleic acid Development and progression DNA Experiments Female Gene expression Gene Expression Regulation, Neoplastic gene rearrangement Gene Rearrangement - genetics Genetic aspects Health aspects Human papillomavirus Humans Ovarian cancer PAX8 PAX8 Transcription Factor - biosynthesis PAX8 Transcription Factor - genetics Properties Protein Isoforms - biosynthesis Protein Isoforms - genetics RNA, Messenger - biosynthesis Studies Thyroid gland Transcription factors Tumors Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology |
| title | PAX8 is transcribed aberrantly in cervical tumors and derived cell lines due to complex gene rearrangements |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T23%3A27%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PAX8%20is%20transcribed%20aberrantly%20in%20cervical%20tumors%20and%20derived%20cell%20lines%20due%20to%20complex%20gene%20rearrangements&rft.jtitle=International%20journal%20of%20oncology&rft.au=L%C3%93PEZ-URRUTIA,%20EDUARDO&rft.date=2016-07-01&rft.volume=49&rft.issue=1&rft.spage=371&rft.epage=380&rft.pages=371-380&rft.issn=1019-6439&rft.eissn=1791-2423&rft_id=info:doi/10.3892/ijo.2016.3515&rft_dat=%3Cgale_proqu%3EA457330681%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932325980&rft_id=info:pmid/27175788&rft_galeid=A457330681&rfr_iscdi=true |