Thunbergia alata inhibits inflammatory responses through the inactivation of ERK and STAT3 in macrophages

Thunbergia alata (Acanthaceae) has been used traditionally to treat various inflammatory diseases such as fever, cough and diarrhea in East African countries including Uganda and Kenya. However, systemic studies elucidating the anti-inflammatory effects and precise mechanisms of action of T. alata h...

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Veröffentlicht in:	International journal of molecular medicine 2016-11, Vol.38 (5), p.1596-1604
Hauptverfasser:	Cho, Young-Chang, Kim, Ye Rang, Kim, Ba Reum, Bach, Tran The, Cho, Sayeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae - chemistry Animals Blotting, Western Care and treatment Cell Line Dose-Response Relationship, Drug Enzyme Activation - drug effects extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression - drug effects Genetic aspects Health aspects Immune system Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - prevention & control Inflammatory diseases interleukin 6 Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Kinases Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - metabolism Materia medica, Vegetable Medical research Methanol - chemistry Mice nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Phosphorylation Phosphorylation - drug effects Phytochemicals Plant extracts Plant Extracts - pharmacology Production increases Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Regulation Reverse Transcriptase Polymerase Chain Reaction signal transducer and activator of transcription 3 Signal transduction STAT3 Transcription Factor - metabolism Studies Thunbergia alata Transcription factors Tumor necrosis factor-TNF tumor necrosis factor-α
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