Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models

Cancer stem cells (CSC) exhibit therapy resistance and drive self-renewal of the tumour, making cancer stem cells an important target for therapy. The PI3K signalling pathway has been the focus of considerable research effort, including in glioblastoma (GBM), a cancer that is notoriously resistant t...

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Veröffentlicht in:	International journal of oncology 2016-07, Vol.49 (1), p.207-216
Hauptverfasser:	JONES, NICOLE M, ROWE, MATTHEW R, SHEPHERD, PETER R, McCONNELL, MELANIE J
Format:	Artikel
Sprache:	eng
Schlagworte:	A66 Analysis BEZ235 Brain cancer cancer stem cell Cancer therapies Care and treatment Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cellular signal transduction Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors Class I Phosphatidylinositol 3-Kinases - genetics Development and progression Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Genotype & phenotype glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - pathology Glioblastomas Health aspects Humans Kinases Medical prognosis Mutation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Oncogene Protein v-akt - genetics Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphorylation PI3K Properties Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Kinase Inhibitors - administration & dosage Signal transduction Signal Transduction - drug effects Stem cells TGX221 TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics Transferases Tumors
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