Telomerase regulation: a key to inhibition? (Review)

Telomerase has been recognized as a common factor in most tumor cells, and in turn a distinctive feature with respect to non-malignant cells. This feature has made telomerase a promising target for cancer therapy. Telomerase studies revealed that it is a multi-subunit complex possessing different le...

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Veröffentlicht in:	International journal of oncology 2013-11, Vol.43 (5), p.1351-1356
Hauptverfasser:	Gómez, Diego L Mengual, Farina, Hernán G, Gómez, Daniel E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use Cancer therapies Cell cycle Cell division Chromosomes Deoxyribonucleic acid DNA Enzymes Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Kinases Localization Neoplasms - drug therapy Neoplasms - enzymology Phosphorylation Proteins Senescence Stem cells Telomerase Telomerase - antagonists & inhibitors Telomerase - metabolism
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