Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma
Manumycin A (Manu A) is a natural antibiotic produced by new Streptomyces strain, exhibiting antitumor and anticancer effects. However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. OSCC is an aggressive type of cancer because of its poor prognosis a...
Gespeichert in:
| Veröffentlicht in: | International journal of oncology 2015-11, Vol.47 (5), p.1954-1962 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1962 |
|---|---|
| container_issue | 5 |
| container_start_page | 1954 |
| container_title | International journal of oncology |
| container_volume | 47 |
| creator | CHO, JUNG JAE CHAE, JUNG-IL KIM, KA HWI CHO, JIN HYOUNG JEON, YOUNG-JOO OH, HA NA YOON, GOO YOON, DO YOUNG CHO, YOUNG SIK CHO, SEUNG-SIK SHIM, JUNG-HYUN |
| description | Manumycin A (Manu A) is a natural antibiotic produced by new Streptomyces strain, exhibiting antitumor and anticancer effects. However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. OSCC is an aggressive type of cancer because of its poor prognosis and low survival rate despite advanced medical treatment. We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. We also observed downregulation of Sp1 downstream target genes such as p27, p21, Mcl-1 and survivin. Moreover, nuclear staining with DAPI showed that Manu A was able to cause nuclear condensation and further fragmentation. Flow cytometry analyses using Annexin V and propiodium iodide supported Manu A-mediated apoptotic cell death of OSCC cells. Furthermore, Bcl-2 family such as mitochondrial pro-apoptotic Bax, anti-apoptotic Bcl-xl and Bid were regulated by Manu A, triggering the mitochondrial apoptotic pathway. In conclusion, these results indicate that Manu A is a potential to treat human OSCC via cell apoptosis through the downregulation of Sp1. |
| doi_str_mv | 10.3892/ijo.2015.3151 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1932313531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1932313531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-96153613796ede2e833c869be8456513bf5ebab96d9931e223a2480d933a76e43</originalsourceid><addsrcrecordid>eNo9kc1u3CAUhVHVqkmnXXZbIXXRFVPDNR6zjKL-SamyaLK2MFzPMLKNw4-ieay8YbEmyQIB4uNwxEfIZ15toVXiuzv6rai43AKX_A255DvFmagFvC3riivW1KAuyIcYj1UlpKz4e3IhGpDlEr8kT3_1nKeTcTO9okPwE9V0xkf6LwVcki8nGGlMQRfAzTavW5ytX0YdJ2dowORMHvO0Qhgjm9A6ndBSg-NILep0oOkQfN4faFzQuMEZl050CT5hCeU0uv2sRzfvywP0kCc9Ux_0SOND1pPP8ZxkdCgl_aQ_kneDHiN-ep435P7nj7vr3-zm9tef66sbZkCJxFTDJTQcdqpBiwJbANM2qse2lo3k0A8Se92rxioFHIUALeq2sgpA7xqsYUO-nnNL04eMMXVHn0NpGjuuQAAHWcaGsDNlgo8x4NAtwU06nDpedaugrgjqVkHdKqjwX55Tc1--6pV-MVKAb2cgLnq2zvr4ypQkVu9YJRlXsob_4n2cYQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1932313531</pqid></control><display><type>article</type><title>Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma</title><source>Spandidos Publications Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>CHO, JUNG JAE ; CHAE, JUNG-IL ; KIM, KA HWI ; CHO, JIN HYOUNG ; JEON, YOUNG-JOO ; OH, HA NA ; YOON, GOO ; YOON, DO YOUNG ; CHO, YOUNG SIK ; CHO, SEUNG-SIK ; SHIM, JUNG-HYUN</creator><creatorcontrib>CHO, JUNG JAE ; CHAE, JUNG-IL ; KIM, KA HWI ; CHO, JIN HYOUNG ; JEON, YOUNG-JOO ; OH, HA NA ; YOON, GOO ; YOON, DO YOUNG ; CHO, YOUNG SIK ; CHO, SEUNG-SIK ; SHIM, JUNG-HYUN</creatorcontrib><description>Manumycin A (Manu A) is a natural antibiotic produced by new Streptomyces strain, exhibiting antitumor and anticancer effects. However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. OSCC is an aggressive type of cancer because of its poor prognosis and low survival rate despite advanced medical treatment. We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. We also observed downregulation of Sp1 downstream target genes such as p27, p21, Mcl-1 and survivin. Moreover, nuclear staining with DAPI showed that Manu A was able to cause nuclear condensation and further fragmentation. Flow cytometry analyses using Annexin V and propiodium iodide supported Manu A-mediated apoptotic cell death of OSCC cells. Furthermore, Bcl-2 family such as mitochondrial pro-apoptotic Bax, anti-apoptotic Bcl-xl and Bid were regulated by Manu A, triggering the mitochondrial apoptotic pathway. In conclusion, these results indicate that Manu A is a potential to treat human OSCC via cell apoptosis through the downregulation of Sp1.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2015.3151</identifier><identifier>PMID: 26352011</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Antibiotics ; Apoptosis ; Apoptosis - drug effects ; Bacterial infections ; Carcinoma, Squamous Cell - drug therapy ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Cell cycle ; Cell death ; Cell division ; Cell growth ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chromatography ; Cyclin-dependent kinases ; Endoplasmic Reticulum Stress - drug effects ; endoplasmic reticulum stress-mediated cell death ; Gene Expression Regulation, Neoplastic ; Humans ; Kinases ; Ligands ; manumycin A ; Mitochondria - drug effects ; Mitochondria - pathology ; Mouth Neoplasms - drug therapy ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Neoplasm Proteins - biosynthesis ; Oral cancer ; oral squamous cell carcinoma ; Polyenes - administration & dosage ; Polyenes - chemistry ; Polyunsaturated Alkamides - administration & dosage ; Polyunsaturated Alkamides - chemistry ; Proteins ; Signal Transduction - drug effects ; Sp1 Transcription Factor - biosynthesis ; Sp1 Transcription Factor - genetics ; specificity protein 1 ; Squamous cell carcinoma ; Streptomyces - chemistry ; Tumor necrosis factor-TNF</subject><ispartof>International journal of oncology, 2015-11, Vol.47 (5), p.1954-1962</ispartof><rights>Copyright: © Cho.</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-96153613796ede2e833c869be8456513bf5ebab96d9931e223a2480d933a76e43</citedby><cites>FETCH-LOGICAL-c392t-96153613796ede2e833c869be8456513bf5ebab96d9931e223a2480d933a76e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26352011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHO, JUNG JAE</creatorcontrib><creatorcontrib>CHAE, JUNG-IL</creatorcontrib><creatorcontrib>KIM, KA HWI</creatorcontrib><creatorcontrib>CHO, JIN HYOUNG</creatorcontrib><creatorcontrib>JEON, YOUNG-JOO</creatorcontrib><creatorcontrib>OH, HA NA</creatorcontrib><creatorcontrib>YOON, GOO</creatorcontrib><creatorcontrib>YOON, DO YOUNG</creatorcontrib><creatorcontrib>CHO, YOUNG SIK</creatorcontrib><creatorcontrib>CHO, SEUNG-SIK</creatorcontrib><creatorcontrib>SHIM, JUNG-HYUN</creatorcontrib><title>Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Manumycin A (Manu A) is a natural antibiotic produced by new Streptomyces strain, exhibiting antitumor and anticancer effects. However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. OSCC is an aggressive type of cancer because of its poor prognosis and low survival rate despite advanced medical treatment. We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. We also observed downregulation of Sp1 downstream target genes such as p27, p21, Mcl-1 and survivin. Moreover, nuclear staining with DAPI showed that Manu A was able to cause nuclear condensation and further fragmentation. Flow cytometry analyses using Annexin V and propiodium iodide supported Manu A-mediated apoptotic cell death of OSCC cells. Furthermore, Bcl-2 family such as mitochondrial pro-apoptotic Bax, anti-apoptotic Bcl-xl and Bid were regulated by Manu A, triggering the mitochondrial apoptotic pathway. In conclusion, these results indicate that Manu A is a potential to treat human OSCC via cell apoptosis through the downregulation of Sp1.</description><subject>Antibiotics</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Bacterial infections</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell division</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chromatography</subject><subject>Cyclin-dependent kinases</subject><subject>Endoplasmic Reticulum Stress - drug effects</subject><subject>endoplasmic reticulum stress-mediated cell death</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Kinases</subject><subject>Ligands</subject><subject>manumycin A</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - pathology</subject><subject>Mouth Neoplasms - drug therapy</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Oral cancer</subject><subject>oral squamous cell carcinoma</subject><subject>Polyenes - administration & dosage</subject><subject>Polyenes - chemistry</subject><subject>Polyunsaturated Alkamides - administration & dosage</subject><subject>Polyunsaturated Alkamides - chemistry</subject><subject>Proteins</subject><subject>Signal Transduction - drug effects</subject><subject>Sp1 Transcription Factor - biosynthesis</subject><subject>Sp1 Transcription Factor - genetics</subject><subject>specificity protein 1</subject><subject>Squamous cell carcinoma</subject><subject>Streptomyces - chemistry</subject><subject>Tumor necrosis factor-TNF</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo9kc1u3CAUhVHVqkmnXXZbIXXRFVPDNR6zjKL-SamyaLK2MFzPMLKNw4-ieay8YbEmyQIB4uNwxEfIZ15toVXiuzv6rai43AKX_A255DvFmagFvC3riivW1KAuyIcYj1UlpKz4e3IhGpDlEr8kT3_1nKeTcTO9okPwE9V0xkf6LwVcki8nGGlMQRfAzTavW5ytX0YdJ2dowORMHvO0Qhgjm9A6ndBSg-NILep0oOkQfN4faFzQuMEZl050CT5hCeU0uv2sRzfvywP0kCc9Ux_0SOND1pPP8ZxkdCgl_aQ_kneDHiN-ep435P7nj7vr3-zm9tef66sbZkCJxFTDJTQcdqpBiwJbANM2qse2lo3k0A8Se92rxioFHIUALeq2sgpA7xqsYUO-nnNL04eMMXVHn0NpGjuuQAAHWcaGsDNlgo8x4NAtwU06nDpedaugrgjqVkHdKqjwX55Tc1--6pV-MVKAb2cgLnq2zvr4ypQkVu9YJRlXsob_4n2cYQ</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>CHO, JUNG JAE</creator><creator>CHAE, JUNG-IL</creator><creator>KIM, KA HWI</creator><creator>CHO, JIN HYOUNG</creator><creator>JEON, YOUNG-JOO</creator><creator>OH, HA NA</creator><creator>YOON, GOO</creator><creator>YOON, DO YOUNG</creator><creator>CHO, YOUNG SIK</creator><creator>CHO, SEUNG-SIK</creator><creator>SHIM, JUNG-HYUN</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20151101</creationdate><title>Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma</title><author>CHO, JUNG JAE ; CHAE, JUNG-IL ; KIM, KA HWI ; CHO, JIN HYOUNG ; JEON, YOUNG-JOO ; OH, HA NA ; YOON, GOO ; YOON, DO YOUNG ; CHO, YOUNG SIK ; CHO, SEUNG-SIK ; SHIM, JUNG-HYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-96153613796ede2e833c869be8456513bf5ebab96d9931e223a2480d933a76e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antibiotics</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Bacterial infections</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell division</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chromatography</topic><topic>Cyclin-dependent kinases</topic><topic>Endoplasmic Reticulum Stress - drug effects</topic><topic>endoplasmic reticulum stress-mediated cell death</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Kinases</topic><topic>Ligands</topic><topic>manumycin A</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - pathology</topic><topic>Mouth Neoplasms - drug therapy</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Oral cancer</topic><topic>oral squamous cell carcinoma</topic><topic>Polyenes - administration & dosage</topic><topic>Polyenes - chemistry</topic><topic>Polyunsaturated Alkamides - administration & dosage</topic><topic>Polyunsaturated Alkamides - chemistry</topic><topic>Proteins</topic><topic>Signal Transduction - drug effects</topic><topic>Sp1 Transcription Factor - biosynthesis</topic><topic>Sp1 Transcription Factor - genetics</topic><topic>specificity protein 1</topic><topic>Squamous cell carcinoma</topic><topic>Streptomyces - chemistry</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHO, JUNG JAE</creatorcontrib><creatorcontrib>CHAE, JUNG-IL</creatorcontrib><creatorcontrib>KIM, KA HWI</creatorcontrib><creatorcontrib>CHO, JIN HYOUNG</creatorcontrib><creatorcontrib>JEON, YOUNG-JOO</creatorcontrib><creatorcontrib>OH, HA NA</creatorcontrib><creatorcontrib>YOON, GOO</creatorcontrib><creatorcontrib>YOON, DO YOUNG</creatorcontrib><creatorcontrib>CHO, YOUNG SIK</creatorcontrib><creatorcontrib>CHO, SEUNG-SIK</creatorcontrib><creatorcontrib>SHIM, JUNG-HYUN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHO, JUNG JAE</au><au>CHAE, JUNG-IL</au><au>KIM, KA HWI</au><au>CHO, JIN HYOUNG</au><au>JEON, YOUNG-JOO</au><au>OH, HA NA</au><au>YOON, GOO</au><au>YOON, DO YOUNG</au><au>CHO, YOUNG SIK</au><au>CHO, SEUNG-SIK</au><au>SHIM, JUNG-HYUN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>47</volume><issue>5</issue><spage>1954</spage><epage>1962</epage><pages>1954-1962</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Manumycin A (Manu A) is a natural antibiotic produced by new Streptomyces strain, exhibiting antitumor and anticancer effects. However, the anticancer effects of Manu A on oral squamous cell carcinoma (OSCC) have not been reported. OSCC is an aggressive type of cancer because of its poor prognosis and low survival rate despite advanced medical treatment. We observed that Manu A reduced cell growth and Sp1 protein levels in OSCC cell lines (HN22 and HSC4) in a dose- and time-dependent manner. We also observed downregulation of Sp1 downstream target genes such as p27, p21, Mcl-1 and survivin. Moreover, nuclear staining with DAPI showed that Manu A was able to cause nuclear condensation and further fragmentation. Flow cytometry analyses using Annexin V and propiodium iodide supported Manu A-mediated apoptotic cell death of OSCC cells. Furthermore, Bcl-2 family such as mitochondrial pro-apoptotic Bax, anti-apoptotic Bcl-xl and Bid were regulated by Manu A, triggering the mitochondrial apoptotic pathway. In conclusion, these results indicate that Manu A is a potential to treat human OSCC via cell apoptosis through the downregulation of Sp1.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26352011</pmid><doi>10.3892/ijo.2015.3151</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1019-6439 |
| ispartof | International journal of oncology, 2015-11, Vol.47 (5), p.1954-1962 |
| issn | 1019-6439 1791-2423 |
| language | eng |
| recordid | cdi_proquest_journals_1932313531 |
| source | Spandidos Publications Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Antibiotics Apoptosis Apoptosis - drug effects Bacterial infections Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell cycle Cell death Cell division Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chromatography Cyclin-dependent kinases Endoplasmic Reticulum Stress - drug effects endoplasmic reticulum stress-mediated cell death Gene Expression Regulation, Neoplastic Humans Kinases Ligands manumycin A Mitochondria - drug effects Mitochondria - pathology Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Mouth Neoplasms - pathology Neoplasm Proteins - biosynthesis Oral cancer oral squamous cell carcinoma Polyenes - administration & dosage Polyenes - chemistry Polyunsaturated Alkamides - administration & dosage Polyunsaturated Alkamides - chemistry Proteins Signal Transduction - drug effects Sp1 Transcription Factor - biosynthesis Sp1 Transcription Factor - genetics specificity protein 1 Squamous cell carcinoma Streptomyces - chemistry Tumor necrosis factor-TNF |
| title | Manumycin A from a new Streptomyces strain induces endoplasmic reticulum stress-mediated cell death through specificity protein 1 signaling in human oral squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T12%3A47%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Manumycin%20A%20from%20a%20new%20Streptomyces%20strain%20induces%20endoplasmic%20reticulum%20stress-mediated%20cell%20death%20through%20specificity%20protein%201%20signaling%20in%20human%20oral%20squamous%20cell%20carcinoma&rft.jtitle=International%20journal%20of%20oncology&rft.au=CHO,%20JUNG%20JAE&rft.date=2015-11-01&rft.volume=47&rft.issue=5&rft.spage=1954&rft.epage=1962&rft.pages=1954-1962&rft.issn=1019-6439&rft.eissn=1791-2423&rft_id=info:doi/10.3892/ijo.2015.3151&rft_dat=%3Cproquest_cross%3E1932313531%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1932313531&rft_id=info:pmid/26352011&rfr_iscdi=true |