Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 signaling pathway in gastric cancer

Gastric cancer is an aggressive disease that continues to have a daunting impact on global health. Fra-1 (FOSL1) plays important roles in oncogenesis in various malignancies. We investigated the expression of Fra-1 in gastric cancer (GC) tissues by qPCR, immunohistochemistry (IHC) and western blot t...

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Veröffentlicht in:	International journal of oncology 2015-11, Vol.47 (5), p.1725-1734
Hauptverfasser:	HE, JUNYU, ZHU, GUANGCHAO, GAO, LU, CHEN, PAN, LONG, YUEHUA, LIAO, SHAN, YI, HONG, YI, WEI, PEI, ZHEN, WU, MINGHUA, LI, XIAOLING, XIANG, JUANJUAN, PENG, SHUPING, MA, JIAN, ZHOU, MING, XIONG, WEI, ZENG, ZHAOYANG, XIANG, BO, TANG, KE, CAO, LI, LI, GUIYUAN, ZHOU, YANHONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Cell Line, Tumor Cell Proliferation - genetics Cortactin - biosynthesis Cortactin - genetics Cytoskeletal Proteins - biosynthesis Cytoskeletal Proteins - genetics Fra-1 Gastric cancer Gene Expression Regulation, Neoplastic Humans Kinases Laboratories p53 Peptides Phosphatidylinositol 3-Kinases - biosynthesis PI3K Proteins Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-fos - biosynthesis Proto-Oncogene Proteins c-fos - genetics signal pathway Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcription factors Tumor Suppressor Protein p53 - biosynthesis
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