RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells

Solid tumors are characterized by acidic extracellular pH (pHe). The present study examined the contribution of small GTP-binding proteins to phospholipase D (PLD) activation of acidic pHe-induced matrix metalloproteinase-9 (MMP-9) production. Acidic pHe-induced MMP-9 production was reduced by C3 ex...

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Veröffentlicht in:	International journal of oncology 2016-03, Vol.48 (3), p.1251-1257
Hauptverfasser:	MAEDA, TOYONOBU, YUZAWA, SATOSHI, SUZUKI, ATSUKO, BABA, YUH, NISHIMURA, YUKIO, KATO, YASUMASA
Format:	Artikel
Sprache:	eng
Schlagworte:	acidic extracellular pHe Actins - chemistry Analysis Animals Cancer cdc42 GTP-Binding Protein - metabolism Cytochalasin D - chemistry Cytomegalovirus Enzymes G proteins Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Growth factors Humans Hydrogen-Ion Concentration Hypoxia Kinases Laboratories Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism matrix metalloproteinase-9 Melanoma Melanoma, Experimental - metabolism Metastasis Mice Neoplasm Metastasis Neuropeptides - metabolism Phospholipase D - metabolism phospholipase D1 Phospholipases Promoter Regions, Genetic rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - metabolism RhoA RNA, Small Interfering - metabolism Signal Transduction Simvastatin - chemistry
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