Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway

Ribosomal protein S15A (RPS15A), which has been identified as a highly conserved 40S ribosomal protein, is essential for cell survival and proliferation. The present study evaluated the functional role of RPS15A in colorectal cancer (CRC), and our investigation found that RPS15A was highly expressed...

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Veröffentlicht in:	International journal of oncology 2016-04, Vol.48 (4), p.1628-1638
Hauptverfasser:	CHEN, JINGWEN, WEI, YE, FENG, QINGYANG, REN, LI, HE, GUODONG, CHANG, WENJU, ZHU, DEXIANG, YI, TUO, LIN, QI, TANG, WENTAO, XU, JIANMIN, QIN, XINYU
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Antigens cell cycle Cell division Cell growth Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cellular signal transduction Classification Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Female Gene expression Gene Expression Regulation, Neoplastic Genes Genetic aspects HCT116 Cells Health aspects HT29 Cells Humans Laboratories Male Medical prognosis Metastasis Multivariate analysis Neoplasm Metastasis p53 Prognosis Properties Proteins ribosomal protein S15A Ribosomal proteins Ribosomal Proteins - genetics Ribosomal Proteins - metabolism Signal Transduction Survival Analysis Tumor Suppressor Protein p53 - metabolism
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