Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity

Altered epigenetic control of gene expression plays a substantial role in tumor development and progression. Accumulating studies suggest that somatic mutations of CREB binding proteins (CBP)/p300 occur in some cancer cells. CBP/p300 possess histone acetyltransferase (HAT) activity, and are involved...

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Veröffentlicht in:	International journal of oncology 2016-02, Vol.48 (2), p.533-540
Hauptverfasser:	INAGAKI, YUJI, SHIRAKI, KATSUYA, SUGIMOTO, KAZUSHI, YADA, TAKAZUMI, TAMEDA, MASAHIKO, OGURA, SUGURU, YAMAMOTO, NORIHIKO, TAKEI, YOSHIYUKI, ITO, MASAAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Benzoates - pharmacology Binding proteins C646 Carcinoma, Hepatocellular - genetics Cell growth Cell Line, Tumor Cell Proliferation - genetics Colorectal cancer CREB binding protein Deoxyribonucleic acid Development and progression DNA Epigenesis, Genetic - genetics Epigenetics Gastric cancer Gene expression Genetic aspects Genetic regulation Health aspects Hematology Hep G2 Cells hepatocellular carcinoma Hepatoma histone acetyltransferase Histone Acetyltransferases - genetics Humans Laminin - genetics Leukemia Liver cancer Liver Neoplasms - genetics Lung cancer Matrix Metalloproteinase 15 - genetics Medical prognosis Metastasis Mutation Neoplasm Invasiveness - genetics Osteopontin - genetics p300 p300-CBP Transcription Factors - genetics Proteins Pyrazoles - pharmacology RNA, Messenger - genetics Studies Transcription factors Transferases
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