Effects of early or late prenatal immune activation in mice on behavioral and neuroanatomical abnormalities relevant to schizophrenia in the adulthood

•Poly I:C injection during gestation alters locomotor activity of the adult offspring.•Poly I:C injection during gestation reduces glucose preference of the adult offspring.•Maternal immune activation leads to neuroanatomical changes in the adult offspring. Maternal immune activation (MIA) during pr...

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Veröffentlicht in:	International journal of developmental neuroscience 2017-05, Vol.58 (1), p.1-8
Hauptverfasser:	da Silveira, Vivian T., Medeiros, Daniel de Castro, Ropke, Jivago, Guidine, Patricia A., Rezende, Gustavo H., Moraes, Marcio Flavio D., Mendes, Eduardo Mazoni A.M., Macedo, Danielle, Moreira, Fabricio A., de Oliveira, Antonio Carlos P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Activation Age Factors Analysis of Variance Anatomy Animal behavior Animals Animals, Newborn Anxiety Brain Brain - diagnostic imaging Brain - embryology Brain - growth & development Brain - pathology Brain architecture Disease Models, Animal Embryo, Mammalian Emotional behavior Female Food Preferences Gestation Immune response Immune system Interferon Inducers - toxicity Intravenous administration Ketamine Ketamine - toxicity Locomotion - physiology Locomotor activity Magnetic Resonance Imaging Mental disorders Mental Disorders - etiology Mice Mice, Inbred C57BL Morphometry Motor task performance Neurodevelopment Neuroimaging NMR Nuclear magnetic resonance Offspring Poly I-C - toxicity Poly I:C Polyinosinic:polycytidylic acid Pregnancy Prenatal Exposure Delayed Effects - physiopathology Prenatal immune activation Risk taking Rodents Schizophrenia Schizophrenia - complications Schizophrenia - diagnostic imaging Schizophrenia - etiology Schizophrenia - pathology Studies Sucrose - administration & dosage Ventricle (lateral)
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