Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring

•Maternal dipyrone treatment during lactation reduced maternal behavior.•Dipyrone treatment alters the onset of physical and neurodevelopmental landmarks.•Maternal dipyrone treatment impact on anxiety-like behavior in offspring. Dipyrone (metamizole), a powerful drug, is widely used as an analgesic...

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Veröffentlicht in:	International journal of developmental neuroscience 2017-05, Vol.58 (1), p.74-81
Hauptverfasser:	Veronesi, Vanessa Barbosa, Batista, Tatiane Helena, Ribeiro, Ana Cláudia Alves Freire, Giusti-Paiva, Alexandre, Vilela, Fabiana Cardoso
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Age Factors Analgesics Animal lactation Animals Animals, Newborn Anti-Inflammatory Agents, Non-Steroidal - toxicity Anxiety Anxiety - chemically induced Behavior Developmental Disabilities - etiology Dipyrone Dipyrone - toxicity Dose-Response Relationship, Drug Drinking Behavior - drug effects Drinking water Effects Emotional behavior Exploratory Behavior - drug effects Female Females Humans Lactation Lactation - drug effects Locomotor activity Male Males Maternal behavior Maternal Behavior - drug effects Maze Learning - drug effects Metamizole Mice Offspring Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Rodents Vocalization, Animal - drug effects
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