Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring
•Maternal dipyrone treatment during lactation reduced maternal behavior.•Dipyrone treatment alters the onset of physical and neurodevelopmental landmarks.•Maternal dipyrone treatment impact on anxiety-like behavior in offspring. Dipyrone (metamizole), a powerful drug, is widely used as an analgesic...
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| Veröffentlicht in: | International journal of developmental neuroscience 2017-05, Vol.58 (1), p.74-81 |
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| creator | Veronesi, Vanessa Barbosa Batista, Tatiane Helena Ribeiro, Ana Cláudia Alves Freire Giusti-Paiva, Alexandre Vilela, Fabiana Cardoso |
| description | •Maternal dipyrone treatment during lactation reduced maternal behavior.•Dipyrone treatment alters the onset of physical and neurodevelopmental landmarks.•Maternal dipyrone treatment impact on anxiety-like behavior in offspring.
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam’s maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring. |
| doi_str_mv | 10.1016/j.ijdevneu.2017.02.005 |
| format | Article |
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Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam’s maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.</description><identifier>ISSN: 0736-5748</identifier><identifier>EISSN: 1873-474X</identifier><identifier>DOI: 10.1016/j.ijdevneu.2017.02.005</identifier><identifier>PMID: 28219765</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adolescents ; Age Factors ; Analgesics ; Animal lactation ; Animals ; Animals, Newborn ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Anxiety ; Anxiety - chemically induced ; Behavior ; Developmental Disabilities - etiology ; Dipyrone ; Dipyrone - toxicity ; Dose-Response Relationship, Drug ; Drinking Behavior - drug effects ; Drinking water ; Effects ; Emotional behavior ; Exploratory Behavior - drug effects ; Female ; Females ; Humans ; Lactation ; Lactation - drug effects ; Locomotor activity ; Male ; Males ; Maternal behavior ; Maternal Behavior - drug effects ; Maze Learning - drug effects ; Metamizole ; Mice ; Offspring ; Pregnancy ; Prenatal Exposure Delayed Effects - chemically induced ; Prenatal Exposure Delayed Effects - physiopathology ; Rodents ; Vocalization, Animal - drug effects</subject><ispartof>International journal of developmental neuroscience, 2017-05, Vol.58 (1), p.74-81</ispartof><rights>2017 ISDN</rights><rights>Copyright © 2017 ISDN. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier BV May 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4625-e3af74455c3c667eb5e2379a23418b9e4873feb51a310040885a3f36e04dbb8c3</citedby><cites>FETCH-LOGICAL-c4625-e3af74455c3c667eb5e2379a23418b9e4873feb51a310040885a3f36e04dbb8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijdevneu.2017.02.005$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijdevneu.2017.02.005$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28219765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veronesi, Vanessa Barbosa</creatorcontrib><creatorcontrib>Batista, Tatiane Helena</creatorcontrib><creatorcontrib>Ribeiro, Ana Cláudia Alves Freire</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><creatorcontrib>Vilela, Fabiana Cardoso</creatorcontrib><title>Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring</title><title>International journal of developmental neuroscience</title><addtitle>Int J Dev Neurosci</addtitle><description>•Maternal dipyrone treatment during lactation reduced maternal behavior.•Dipyrone treatment alters the onset of physical and neurodevelopmental landmarks.•Maternal dipyrone treatment impact on anxiety-like behavior in offspring.
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam’s maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.</description><subject>Adolescents</subject><subject>Age Factors</subject><subject>Analgesics</subject><subject>Animal lactation</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Anxiety</subject><subject>Anxiety - chemically induced</subject><subject>Behavior</subject><subject>Developmental Disabilities - etiology</subject><subject>Dipyrone</subject><subject>Dipyrone - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking Behavior - drug effects</subject><subject>Drinking water</subject><subject>Effects</subject><subject>Emotional behavior</subject><subject>Exploratory Behavior - drug effects</subject><subject>Female</subject><subject>Females</subject><subject>Humans</subject><subject>Lactation</subject><subject>Lactation - drug effects</subject><subject>Locomotor activity</subject><subject>Male</subject><subject>Males</subject><subject>Maternal behavior</subject><subject>Maternal Behavior - drug effects</subject><subject>Maze Learning - drug effects</subject><subject>Metamizole</subject><subject>Mice</subject><subject>Offspring</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Rodents</subject><subject>Vocalization, Animal - drug effects</subject><issn>0736-5748</issn><issn>1873-474X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAURi0EokPhFSpLrBP8G2d2oHYKMyplQxE7y3FuwCFxBjsZmFVfvY7SgSWsLF2fe_z5Q-iCkpwSWrxpc9fWcPAw5YxQlROWEyKfoBUtFc-EEl-fohVRvMikEuUZehFjSxIhiXiOzljJ6FoVcoXuP5oRgjcdrt3-GAYPeAxgxh78iOspOP8Nd8aOZnSDx87j3lnAAerJQsT9abmC7-bghoCNrxNlkyKme-N_OxiPWed-wF8mWYamiftZ_hI9a0wX4dXjeY7urjefLz9kN5_eby_f3WRWFExmwE2jhJDSclsUCioJjKu1YVzQslqDSL9u0pQaTgkRpCyl4Q0vgIi6qkrLz9HrxbsPw88J4qjbYZqjR03XnFGqFGWJKhbKhiHGAI1OIXsTjpoSPfeuW33qXc-9a8J0ajUtXjzqp6qH-s_aqegEbBfgl-vg-J9avbu63W13V5svt5u7eU7Y8tjbxQWpsIODoKN14C3ULoAddT24f-V9AIilsGY</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Veronesi, Vanessa Barbosa</creator><creator>Batista, Tatiane Helena</creator><creator>Ribeiro, Ana Cláudia Alves Freire</creator><creator>Giusti-Paiva, Alexandre</creator><creator>Vilela, Fabiana Cardoso</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201705</creationdate><title>Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring</title><author>Veronesi, Vanessa Barbosa ; Batista, Tatiane Helena ; Ribeiro, Ana Cláudia Alves Freire ; Giusti-Paiva, Alexandre ; Vilela, Fabiana Cardoso</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4625-e3af74455c3c667eb5e2379a23418b9e4873feb51a310040885a3f36e04dbb8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescents</topic><topic>Age Factors</topic><topic>Analgesics</topic><topic>Animal lactation</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Anxiety</topic><topic>Anxiety - chemically induced</topic><topic>Behavior</topic><topic>Developmental Disabilities - etiology</topic><topic>Dipyrone</topic><topic>Dipyrone - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking Behavior - drug effects</topic><topic>Drinking water</topic><topic>Effects</topic><topic>Emotional behavior</topic><topic>Exploratory Behavior - drug effects</topic><topic>Female</topic><topic>Females</topic><topic>Humans</topic><topic>Lactation</topic><topic>Lactation - drug effects</topic><topic>Locomotor activity</topic><topic>Male</topic><topic>Males</topic><topic>Maternal behavior</topic><topic>Maternal Behavior - drug effects</topic><topic>Maze Learning - drug effects</topic><topic>Metamizole</topic><topic>Mice</topic><topic>Offspring</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Rodents</topic><topic>Vocalization, Animal - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veronesi, Vanessa Barbosa</creatorcontrib><creatorcontrib>Batista, Tatiane Helena</creatorcontrib><creatorcontrib>Ribeiro, Ana Cláudia Alves Freire</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><creatorcontrib>Vilela, Fabiana Cardoso</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>International journal of developmental neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veronesi, Vanessa Barbosa</au><au>Batista, Tatiane Helena</au><au>Ribeiro, Ana Cláudia Alves Freire</au><au>Giusti-Paiva, Alexandre</au><au>Vilela, Fabiana Cardoso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring</atitle><jtitle>International journal of developmental neuroscience</jtitle><addtitle>Int J Dev Neurosci</addtitle><date>2017-05</date><risdate>2017</risdate><volume>58</volume><issue>1</issue><spage>74</spage><epage>81</epage><pages>74-81</pages><issn>0736-5748</issn><eissn>1873-474X</eissn><abstract>•Maternal dipyrone treatment during lactation reduced maternal behavior.•Dipyrone treatment alters the onset of physical and neurodevelopmental landmarks.•Maternal dipyrone treatment impact on anxiety-like behavior in offspring.
Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam’s maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28219765</pmid><doi>10.1016/j.ijdevneu.2017.02.005</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescents Age Factors Analgesics Animal lactation Animals Animals, Newborn Anti-Inflammatory Agents, Non-Steroidal - toxicity Anxiety Anxiety - chemically induced Behavior Developmental Disabilities - etiology Dipyrone Dipyrone - toxicity Dose-Response Relationship, Drug Drinking Behavior - drug effects Drinking water Effects Emotional behavior Exploratory Behavior - drug effects Female Females Humans Lactation Lactation - drug effects Locomotor activity Male Males Maternal behavior Maternal Behavior - drug effects Maze Learning - drug effects Metamizole Mice Offspring Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Rodents Vocalization, Animal - drug effects |
| title | Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety-like behavior in offspring |
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