TUSC 3: a novel tumour suppressor gene and its functional implications
The tumour suppressor candidate 3 ( TUSC 3) gene is located on chromosome region 8p22 and encodes the 34 kD TUSC 3 protein, which is a subunit of the oligosaccharyl transferase responsible for the N ‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for...
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| Veröffentlicht in: | Journal of cellular and molecular medicine 2017-09, Vol.21 (9), p.1711-1718 |
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| container_title | Journal of cellular and molecular medicine |
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| creator | Yu, Xinshuang Zhai, Chunjuan Fan, Yujun Zhang, Jiandong Liang, Ning Liu, Fengjun Cao, Lili Wang, Jia Du, Juan |
| description | The tumour suppressor candidate 3 (
TUSC
3) gene is located on chromosome region 8p22 and encodes the 34 kD
TUSC
3 protein, which is a subunit of the oligosaccharyl transferase responsible for the
N
‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years,
TUSC
3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of
TUSC
3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that
TUSC
3 is an Mg
2+
‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of
TUSC
3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of
TUSC
3 and comment on the potential roles of
TUSC
3 in diagnosis and treatment of
TUSC
3‐related diseases, especially cancer. |
| doi_str_mv | 10.1111/jcmm.13128 |
| format | Article |
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TUSC
3) gene is located on chromosome region 8p22 and encodes the 34 kD
TUSC
3 protein, which is a subunit of the oligosaccharyl transferase responsible for the
N
‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years,
TUSC
3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of
TUSC
3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that
TUSC
3 is an Mg
2+
‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of
TUSC
3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of
TUSC
3 and comment on the potential roles of
TUSC
3 in diagnosis and treatment of
TUSC
3‐related diseases, especially cancer.</description><identifier>ISSN: 1582-1838</identifier><identifier>EISSN: 1582-4934</identifier><identifier>DOI: 10.1111/jcmm.13128</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Inc</publisher><subject>Cancer ; Clonal deletion ; Embryogenesis ; Embryonic growth stage ; Endoplasmic reticulum ; Genes ; Genetic transformation ; Glycosylation ; Homeostasis ; Learning ; Magnesium ; Memory ; Proteins ; Structure-function relationships ; Tumors</subject><ispartof>Journal of cellular and molecular medicine, 2017-09, Vol.21 (9), p.1711-1718</ispartof><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1049-5bfdd49773b5acdf74548c8df5f3a44002348ab89b236c846dcfc9d811efe9923</citedby><cites>FETCH-LOGICAL-c1049-5bfdd49773b5acdf74548c8df5f3a44002348ab89b236c846dcfc9d811efe9923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27903,27904</link.rule.ids></links><search><creatorcontrib>Yu, Xinshuang</creatorcontrib><creatorcontrib>Zhai, Chunjuan</creatorcontrib><creatorcontrib>Fan, Yujun</creatorcontrib><creatorcontrib>Zhang, Jiandong</creatorcontrib><creatorcontrib>Liang, Ning</creatorcontrib><creatorcontrib>Liu, Fengjun</creatorcontrib><creatorcontrib>Cao, Lili</creatorcontrib><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Du, Juan</creatorcontrib><title>TUSC 3: a novel tumour suppressor gene and its functional implications</title><title>Journal of cellular and molecular medicine</title><description>The tumour suppressor candidate 3 (
TUSC
3) gene is located on chromosome region 8p22 and encodes the 34 kD
TUSC
3 protein, which is a subunit of the oligosaccharyl transferase responsible for the
N
‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years,
TUSC
3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of
TUSC
3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that
TUSC
3 is an Mg
2+
‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of
TUSC
3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of
TUSC
3 and comment on the potential roles of
TUSC
3 in diagnosis and treatment of
TUSC
3‐related diseases, especially cancer.</description><subject>Cancer</subject><subject>Clonal deletion</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Endoplasmic reticulum</subject><subject>Genes</subject><subject>Genetic transformation</subject><subject>Glycosylation</subject><subject>Homeostasis</subject><subject>Learning</subject><subject>Magnesium</subject><subject>Memory</subject><subject>Proteins</subject><subject>Structure-function relationships</subject><subject>Tumors</subject><issn>1582-1838</issn><issn>1582-4934</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNotkEtLxDAUhYMoOI5u_AUBd0LHpDdpE3dSHBUGXDizDmke0tKXSSv4721n5mzuOXC4HD6E7inZ0FlPtWnbDQWaigu0olykCZPALs-eChDX6CbGmhDIKMgV2u4PXwWGZ6xx1_-6Bo9T208Bx2kYgouxD_jbdQ7rzuJqjNhPnRmrvtMNrtqhqYxeUrxFV1430d2d7xodtq_74j3Zfb59FC-7xFDCZMJLby2TeQ4l18b6nHEmjLCee9CMEZICE7oUskwhM4Jl1ngjraDUeSdlCmv0cPo7hP5ncnFU9bx2XhMVlZASTjiXc-vx1DKhjzE4r4ZQtTr8KUrUwkktnNSRE_wD0ohaxw</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Yu, Xinshuang</creator><creator>Zhai, Chunjuan</creator><creator>Fan, Yujun</creator><creator>Zhang, Jiandong</creator><creator>Liang, Ning</creator><creator>Liu, Fengjun</creator><creator>Cao, Lili</creator><creator>Wang, Jia</creator><creator>Du, Juan</creator><general>John Wiley & Sons, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>201709</creationdate><title>TUSC 3: a novel tumour suppressor gene and its functional implications</title><author>Yu, Xinshuang ; Zhai, Chunjuan ; Fan, Yujun ; Zhang, Jiandong ; Liang, Ning ; Liu, Fengjun ; Cao, Lili ; Wang, Jia ; Du, Juan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1049-5bfdd49773b5acdf74548c8df5f3a44002348ab89b236c846dcfc9d811efe9923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Cancer</topic><topic>Clonal deletion</topic><topic>Embryogenesis</topic><topic>Embryonic growth stage</topic><topic>Endoplasmic reticulum</topic><topic>Genes</topic><topic>Genetic transformation</topic><topic>Glycosylation</topic><topic>Homeostasis</topic><topic>Learning</topic><topic>Magnesium</topic><topic>Memory</topic><topic>Proteins</topic><topic>Structure-function relationships</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Xinshuang</creatorcontrib><creatorcontrib>Zhai, Chunjuan</creatorcontrib><creatorcontrib>Fan, Yujun</creatorcontrib><creatorcontrib>Zhang, Jiandong</creatorcontrib><creatorcontrib>Liang, Ning</creatorcontrib><creatorcontrib>Liu, Fengjun</creatorcontrib><creatorcontrib>Cao, Lili</creatorcontrib><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Du, Juan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Journal of cellular and molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Xinshuang</au><au>Zhai, Chunjuan</au><au>Fan, Yujun</au><au>Zhang, Jiandong</au><au>Liang, Ning</au><au>Liu, Fengjun</au><au>Cao, Lili</au><au>Wang, Jia</au><au>Du, Juan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TUSC 3: a novel tumour suppressor gene and its functional implications</atitle><jtitle>Journal of cellular and molecular medicine</jtitle><date>2017-09</date><risdate>2017</risdate><volume>21</volume><issue>9</issue><spage>1711</spage><epage>1718</epage><pages>1711-1718</pages><issn>1582-1838</issn><eissn>1582-4934</eissn><abstract>The tumour suppressor candidate 3 (
TUSC
3) gene is located on chromosome region 8p22 and encodes the 34 kD
TUSC
3 protein, which is a subunit of the oligosaccharyl transferase responsible for the
N
‐glycosylation of nascent proteins. Known to be related to autosomal recessive mental retardation for several years,
TUSC
3 has only recently been identified as a potential tumour suppressor gene. Based on the structure and function of
TUSC
3, specific mechanisms in various diseases have been investigated. Several studies have demonstrated that
TUSC
3 is an Mg
2+
‐transporter involved in magnesium transport and homeostasis, which is important for learning and memory, embryonic development and testis maturation. Moreover, dysfunction or deletion of
TUSC
3 exerts its oncological effects as a modulator by inhibiting glycosylation efficiency and consequently inducing endoplasmic reticulum stress and malignant cell transformation. In this study, we summarize the advances in the studies of
TUSC
3 and comment on the potential roles of
TUSC
3 in diagnosis and treatment of
TUSC
3‐related diseases, especially cancer.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1111/jcmm.13128</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cellular and molecular medicine, 2017-09, Vol.21 (9), p.1711-1718 |
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| language | eng |
| recordid | cdi_proquest_journals_1932050559 |
| source | Wiley Online Library - AutoHoldings Journals; DOAJ Directory of Open Access Journals; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Cancer Clonal deletion Embryogenesis Embryonic growth stage Endoplasmic reticulum Genes Genetic transformation Glycosylation Homeostasis Learning Magnesium Memory Proteins Structure-function relationships Tumors |
| title | TUSC 3: a novel tumour suppressor gene and its functional implications |
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