Renal and Vascular Effects of Uric Acid Lowering in Normouricemic Patients With Uncomplicated Type 1 Diabetes

Higher plasma uric acid (PUA) levels are associated with lower glomerular filtration rate (GFR) and higher blood pressure (BP) in patients with type 1 diabetes (T1D). Our aim was to determine the impact of PUA lowering on renal and vascular function in patients with uncomplicated T1D. T1D patients (...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2017-07, Vol.66 (7), p.1939-1949
Hauptverfasser:	Lytvyn, Yuliya, Har, Ronnie, Locke, Amy, Lai, Vesta, Fong, Derek, Advani, Andrew, Perkins, Bruce A, Cherney, David Z I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aldosterone Angiotensin Angiotensin II Angiotensin II - pharmacology Blood Pressure Case-Control Studies Clinical trials Cytokines Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Diabetes Mellitus, Type 1 - physiopathology Febuxostat - therapeutic use Female Glomerular filtration rate Glomerular Filtration Rate - drug effects Glomerular Filtration Rate - physiology Gout Suppressants - therapeutic use Humans Hyperglycemia Hyperglycemia - metabolism Hyperglycemia - physiopathology Hypertension Inflammation Interleukin 18 Interleukin-18 - metabolism Inulin Kidneys Linear Models Male Mathematical models Nitric oxide Nitric Oxide - urine Nitroglycerin Nitroglycerin - pharmacology Renal function Renal Plasma Flow, Effective - drug effects Renal Plasma Flow, Effective - physiology Renin Renin-Angiotensin System - drug effects Renin-Angiotensin System - physiology Sensory neurons Uric acid Uric Acid - blood Vascular Stiffness Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilation - physiology Vasodilator Agents - pharmacology Young Adult
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