Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase d mutation in human cells

Mutations in the POLD1 and POLE genes encoding DNA polymerases d (Pold) and ? (Pol?) cause hereditary colorectal cancer (CRC) and have been found in many sporadic colorectal and endometrial tumors. Much attention has been focused on POLE exonuclease domain mutations, which occur frequently in hyperm...

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