Kleine–Levin syndrome elicited by encephalopathy with reversible splenial lesion
Kleine–Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI)...
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| Veröffentlicht in: | Pediatrics international 2017-08, Vol.59 (8), p.929-931 |
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| creator | Takayanagi, Masaru Okabe, Shinichi Yamamoto, Katsuya Komatsu, Juri Suzuki, Rikio Kitamura, Taro Ohura, Toshihiro |
| description | Kleine–Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5–10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine–Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine–Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness. |
| doi_str_mv | 10.1111/ped.13326 |
| format | Article |
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We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5–10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine–Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine–Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.13326</identifier><identifier>PMID: 28804979</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Brain Diseases ; clinically mild encephalitis/encephalopathy with a reversible splenial lesion ; Cognition ; Consciousness ; Corpus callosum ; Corpus Callosum - diagnostic imaging ; Drowsiness ; EEG ; Encephalitis, Viral - complications ; Encephalitis, Viral - diagnostic imaging ; Encephalopathy ; Etiology ; Fatigue ; Female ; Humans ; Hypersomnia ; Influenza A ; Influenza A virus ; influenza encephalopathy ; Influenza, Human - complications ; Influenza, Human - diagnosis ; Kleine-Levin Syndrome - diagnostic imaging ; Kleine-Levin Syndrome - etiology ; Lesions ; Magnetic Resonance Imaging ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Pediatrics ; periodic hypersomnolence ; recurrent hypersomnia ; Sleep ; Sleep disorders</subject><ispartof>Pediatrics international, 2017-08, Vol.59 (8), p.929-931</ispartof><rights>2017 Japan Pediatric Society</rights><rights>2017 Japan Pediatric Society.</rights><rights>Copyright © 2017 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3446-41481a7f09120cc87de09207aabf5c4672d42db57333646e0186af468842d1043</citedby><cites>FETCH-LOGICAL-c3446-41481a7f09120cc87de09207aabf5c4672d42db57333646e0186af468842d1043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.13326$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.13326$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28804979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takayanagi, Masaru</creatorcontrib><creatorcontrib>Okabe, Shinichi</creatorcontrib><creatorcontrib>Yamamoto, Katsuya</creatorcontrib><creatorcontrib>Komatsu, Juri</creatorcontrib><creatorcontrib>Suzuki, Rikio</creatorcontrib><creatorcontrib>Kitamura, Taro</creatorcontrib><creatorcontrib>Ohura, Toshihiro</creatorcontrib><title>Kleine–Levin syndrome elicited by encephalopathy with reversible splenial lesion</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Kleine–Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5–10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine–Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine–Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.</description><subject>Adolescent</subject><subject>Brain Diseases</subject><subject>clinically mild encephalitis/encephalopathy with a reversible splenial lesion</subject><subject>Cognition</subject><subject>Consciousness</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - diagnostic imaging</subject><subject>Drowsiness</subject><subject>EEG</subject><subject>Encephalitis, Viral - complications</subject><subject>Encephalitis, Viral - diagnostic imaging</subject><subject>Encephalopathy</subject><subject>Etiology</subject><subject>Fatigue</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersomnia</subject><subject>Influenza A</subject><subject>Influenza A virus</subject><subject>influenza encephalopathy</subject><subject>Influenza, Human - complications</subject><subject>Influenza, Human - diagnosis</subject><subject>Kleine-Levin Syndrome - diagnostic imaging</subject><subject>Kleine-Levin Syndrome - etiology</subject><subject>Lesions</subject><subject>Magnetic Resonance Imaging</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pediatrics</subject><subject>periodic hypersomnolence</subject><subject>recurrent hypersomnia</subject><subject>Sleep</subject><subject>Sleep disorders</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUhgdRbK0ufAEJuHKRdm6dTJZS6wULiii4GybJCZ0yTeJML2TnO_iGPomjaZeezTn8fPwHPoTOCR6SMKMGiiFhjIoD1Cec05hi_H4YbkZlLLFIeujE-wXGWCaSH6MelRLzNEn76OXRgqng-_NrBhtTRb6tClcvIQJrcrOCIsraCKocmrm2daNX8zbamtU8crAB501mIfKNhcpoG1nwpq5O0VGprYez3R6gt9vp6-Q-nj3dPUyuZ3HOOBcxJ1wSnZQ4JRTnuUwKwCnFidZZOc65SGjBaZGNE8aY4AIwkUKXXEgZYoI5G6DLrrdx9cca_Eot6rWrwktFUiopTceEBOqqo3JXe--gVI0zS-1aRbD6taeCPfVnL7AXu8Z1tgzpntzrCsCoA7bGQvt_k3qe3nSVP2DTeUI</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Takayanagi, Masaru</creator><creator>Okabe, Shinichi</creator><creator>Yamamoto, Katsuya</creator><creator>Komatsu, Juri</creator><creator>Suzuki, Rikio</creator><creator>Kitamura, Taro</creator><creator>Ohura, Toshihiro</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>201708</creationdate><title>Kleine–Levin syndrome elicited by encephalopathy with reversible splenial lesion</title><author>Takayanagi, Masaru ; Okabe, Shinichi ; Yamamoto, Katsuya ; Komatsu, Juri ; Suzuki, Rikio ; Kitamura, Taro ; Ohura, Toshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3446-41481a7f09120cc87de09207aabf5c4672d42db57333646e0186af468842d1043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Brain Diseases</topic><topic>clinically mild encephalitis/encephalopathy with a reversible splenial lesion</topic><topic>Cognition</topic><topic>Consciousness</topic><topic>Corpus callosum</topic><topic>Corpus Callosum - diagnostic imaging</topic><topic>Drowsiness</topic><topic>EEG</topic><topic>Encephalitis, Viral - complications</topic><topic>Encephalitis, Viral - diagnostic imaging</topic><topic>Encephalopathy</topic><topic>Etiology</topic><topic>Fatigue</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersomnia</topic><topic>Influenza A</topic><topic>Influenza A virus</topic><topic>influenza encephalopathy</topic><topic>Influenza, Human - complications</topic><topic>Influenza, Human - diagnosis</topic><topic>Kleine-Levin Syndrome - diagnostic imaging</topic><topic>Kleine-Levin Syndrome - etiology</topic><topic>Lesions</topic><topic>Magnetic Resonance Imaging</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pediatrics</topic><topic>periodic hypersomnolence</topic><topic>recurrent hypersomnia</topic><topic>Sleep</topic><topic>Sleep disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takayanagi, Masaru</creatorcontrib><creatorcontrib>Okabe, Shinichi</creatorcontrib><creatorcontrib>Yamamoto, Katsuya</creatorcontrib><creatorcontrib>Komatsu, Juri</creatorcontrib><creatorcontrib>Suzuki, Rikio</creatorcontrib><creatorcontrib>Kitamura, Taro</creatorcontrib><creatorcontrib>Ohura, Toshihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takayanagi, Masaru</au><au>Okabe, Shinichi</au><au>Yamamoto, Katsuya</au><au>Komatsu, Juri</au><au>Suzuki, Rikio</au><au>Kitamura, Taro</au><au>Ohura, Toshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kleine–Levin syndrome elicited by encephalopathy with reversible splenial lesion</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2017-08</date><risdate>2017</risdate><volume>59</volume><issue>8</issue><spage>929</spage><epage>931</epage><pages>929-931</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Kleine–Levin syndrome is a rare sleep disorder of unknown etiology characterized by repetitive episodes of hypersomnia between asymptomatic periods. We report the case of a 13‐year‐old girl who presented with drowsiness triggered by influenza A as the first episode. Magnetic resonance imaging (MRI) on day 6 showed transient reduction of diffusion in the corpus callosum splenium. The patient was diagnosed with encephalopathy with a reversible splenial lesion. The symptoms resolved after 10 days, but additional episodes of hypersomnia lasting 5–10 days occurred 1, 5, 6, 11, 13, and 25 months after the first episode. MRI during hypersomnia indicated no lesions, and sleep duration and cognition were normal between episodes. The patient was diagnosed with Kleine–Levin syndrome. Electroencephalographic and clinical findings during the first episode were similar to those during the other episodes. Encephalopathy with a splenial lesion and Kleine–Levin syndrome may have similar pathological mechanisms causing a disturbance in consciousness.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>28804979</pmid><doi>10.1111/ped.13326</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Brain Diseases clinically mild encephalitis/encephalopathy with a reversible splenial lesion Cognition Consciousness Corpus callosum Corpus Callosum - diagnostic imaging Drowsiness EEG Encephalitis, Viral - complications Encephalitis, Viral - diagnostic imaging Encephalopathy Etiology Fatigue Female Humans Hypersomnia Influenza A Influenza A virus influenza encephalopathy Influenza, Human - complications Influenza, Human - diagnosis Kleine-Levin Syndrome - diagnostic imaging Kleine-Levin Syndrome - etiology Lesions Magnetic Resonance Imaging Neuroimaging NMR Nuclear magnetic resonance Pediatrics periodic hypersomnolence recurrent hypersomnia Sleep Sleep disorders |
| title | Kleine–Levin syndrome elicited by encephalopathy with reversible splenial lesion |
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