An investigation of the anti-inflammatory effects and a potential biomarker of PI3K[delta] inhibition in COPD T cells

Summary Lymphocyte numbers are increased in the lungs of chronic obstructive pulmonary disease (COPD) patients. Phosphatidylinositol-3-kinase delta (PI3K[delta]) is involved in lymphocyte activation. We investigated the effect of PI3K[delta] inhibition on cytokine release from COPD lymphocytes. We a...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2017-09, Vol.44 (9), p.932
Hauptverfasser:	Khan, Abid, Southworth, Thomas, Worsley, Sally, Sriskantharajah, Srividya, Amour, Augustin, Hessel, Edith M, Singh, Dave
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Alveoli Biomarkers Bronchus Cell activation Chronic obstructive pulmonary disease Cytokines Flow cytometry Inflammation Interferon Interleukin 10 Interleukin 17 Investigations Kinases Leukocytes (mononuclear) Lung diseases Lungs Lymphocytes Lymphocytes T Obstructive lung disease Peripheral blood mononuclear cells Phosphorylation Respiratory tract Ribosomal protein S6 Smoking T cell receptors
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